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　TAO Tao,ZHONG Xing - ming *,GAO Jian - qun,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2013,(03):0.
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广州市乙型肝炎病毒母婴传播阻断实施3年分析

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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

Author(s):: TAO Tao 1 ; ZHONG Xing - ming 2* ; GAO Jian - qun 3 ; SONG Yan - yan 3 ; CUI Qiao - chan 1.; Department of Gynaecology and Obstetrics,BaiYun Dictrict The People’s Hospital in GuangZhou City,Guangzhou Guangdong 510600, P. R. China; 2. Guangdong Provincial Family Planning Science and Technology Research Institute,Guangzhou Guangdong 510600, P. R. China; 3. Guangzhou Women and Children Medical Center, Guangzhou Guangdong 510600,P. R. China

摘要:: 目的探讨孕晚期应用乙型肝炎免疫球蛋白(anti-hepatis B immuneglobulin,HBIG)对阻断乙型肝炎病毒(hepatitis B virus,HBV)母婴垂直传播的作用。方法回顾性分析2009～2011年在广州市妇女儿童中心和广州市白云区人民医院产前检查并分娩的孕妇共30441例。结果筛查出HBV携带者3682例,HBV携带率为12.10%。HBV携带者中2651例于孕晚期进行HBIG肌肉注射被动免疫治疗,其中684例自孕28周起每月肌肉注射HBIG 200 IU共3次,1967例为新生儿出生前后1个月各肌肉注射HBIG 100 IU共2次。孕晚期应用2次或3次HBIG的新生儿及6月龄婴儿乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)阳性率比较差异无统计学意义(P>0.05);出生当天新生儿外周血HBsAg阳性率孕晚期被动免疫治疗组3.62%(96/2651),未治疗组26.38%(272/1031),差异有统计学意义(P<0.05);而未治疗组HBV疫苗免疫后的6个月龄婴儿外周血HBsAb阳转率为30.15%(82/272),显著低于被动免疫治疗组69.79%(67/96),差异有统计学意义(P<0.05)。结论孕晚期注射HBIG可有效阻断HBV的母婴传播。

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更新日期/Last Update: 2013-06-30