[1]刘小燕.地屈孕酮治疗先兆流产剂量与效果的相关性研究[J].中国计划生育和妇产科,2018,(7):90-92.
　LIU Xiao-yan.Study on the correlation between the effect and dose of dydrogesterone in the treatment of threatened abortion[J].Chinese Journal of Family Planning & Gynecotokology,2018,(7):90-92.
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地屈孕酮治疗先兆流产剂量与效果的相关性研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年7期
页码:
90-92
栏目:
论著与临床
出版日期:
2018-07-25

文章信息/Info

Title:
Study on the correlation between the effect and dose of dydrogesterone in the treatment of threatened abortion
作者:
刘小燕
内江市第二人民医院药剂科
Author(s):
LIU Xiao-yan
Pharmacy,The Second People’s Hospital of Neijiang，Neijiang Sichuan 641100，P.R.China
关键词:
地屈孕酮; 先兆流产; 剂量
Keywords:
dydrogesterone;  threatened abortion;  dosage
分类号:
R 714.21
摘要:
目的研究不同剂量的地屈孕酮用于治疗先兆流产的临床效果。方法将2014~2016年内江市第二人民医院诊治的先兆流产患者252例根据随机数字表法分为3组，每组各84例，即A组（10 mg，8 h/次），B组（首剂40 mg，然后10 mg/12 h）和C组（首剂40 mg，然后10 mg/8 h），均用药至临床症状消失后3～7 d。比较3组患者的临床症状缓解和消失时间、治疗效果和不良反应发生率。 结果B组、C组的症状缓解时间和消失时间均短于A组（P<005），B组与C组比较差异无统计学意义（P＞005）；B组、C组的治愈率明显高于A组，差异有统计学意义（P<0.05），B组与C组比较差异无统计学意义（P＞005）；3组不良反应率比较差异无统计学意义（P>0.05）。结论地屈孕酮用于先兆流产的适宜剂量为首剂40 mg，然后10 mg 每12 h或8 h口服1次至临床症状消失后3～7 d，能够保证治疗效果，降低不良反应发生率。
Abstract:
ObjectiveTo study the clinical effects of different doses of dydrogesterone in the treatment of threatened abortion. MethodsA total of 252 patients with threatened abortion in The Second People’s Hospital of Neijiang from 2014 to 2016 were collected and divided into three groups according to the random number table method, with 84 cases in each group. Group A (10 mg, 8 h/time), Group B (40 mg first then 10 mg, 12 h/time) and Group C (40 mg first and then 10 mg, 8 h/time) were administered until 3 to 7 days after the disappearance of clinical symptoms. The clinical symptom remission and disappearance time, treatment effect and incidence of adverse reactions were compared among the 3 groups of patients. ResultsThe remission and disappearance time of group B and C were both significantly less than group A(P<005),while they in group B and C was no statistical difference(P＞005).The cure rate of group B and C were both significantly higher than group A, differences were statistically significant(P<005).There was no significant difference between group B and group C.What’s more,the incidence of adverse reactions in the three groups was of no statistical difference(P＞005).ConclusionThe appropriate dose of dydrogesterone for threatened abortion is 40 mg as the first dose, then 10 mg every 12 hours or 8 hours orally until 3 to 7 days after the disappearance of clinical symptoms, which can guarantee the therapeutic effect and reduce the incidence of adverse reactions.

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更新日期/Last Update: 2018-07-25