[1]赵祖英*,梁劲劲,陆洁清.重度子痫前期患者胎盘组织TGF-β1及MMP-9的表达及意义[J].中国计划生育和妇产科,2017,(10):45-47.
　ZHAO Zu-ying*,LIANG Jin-jin,LU Jie-qing.Expression and significance of TGF-β1 and MMP-9 in placenta of patients with severe preeclampsia[J].Chinese Journal of Family Planning & Gynecotokology,2017,(10):45-47.
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重度子痫前期患者胎盘组织TGF-β1及MMP-9的表达及意义
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2017年10期
页码:
45-47
栏目:
论著与临床
出版日期:
2017-10-25

文章信息/Info

Title:
Expression and significance of TGF-β1 and MMP-9 in placenta of patients with severe preeclampsia
作者:
赵祖英1*; 梁劲劲2; 陆洁清1
梧州市人民医院， 1. 妇产科；2.病理科
Author(s):
ZHAO Zu-ying1*;  LIANG Jin-jin2;  LU Jie-qing1
1. Department of Obstetrics and Gynecology;2.Department of Pathology, Wuzhou People's Hospital , Wuzhou Guangxi 543000,P.R.China
关键词:
子痫前期; 胎盘; TGF-β1; MMP-9
Keywords:
preeclampsia;  placenta;  TGF-β1;  MMP-9
分类号:
R 714.24+5
摘要:
目的研究转化生长因子-β1（transforming growth factor beta 1,TGF-β1)及基质金属蛋白酶-9（matrix metalloproteinase-9,MMP-9）在重度子痫前期患者胎盘组织的表达及其临床意义。方法 Western blot方法对50例正常妊娠组和60例子痫前期组（25例轻度和35例重度）胎盘组织中TGF-β1、MMP-9的表达进行分析。其中早发型轻度子痫前期组15例，晚发型轻度子痫前期组10例；早发型重度子痫前期组18例，晚发型重度子痫前期组17例。结果在重度子痫前期组中TGF-β1的表达明显升高，MMP-9的表达明显降低，与轻度子痫前期组及正常妊娠组相比，差异有统计学意义（P<005）。轻度子痫组与正常妊娠组之间比较差异无统计学意义（P＞005）；胎盘组织中TGF-β1的表达水平和MMP-9的表达水平呈负相关（P<005）；TGF-β1、MMP-9在子痫前期患者早发型和晚发型组间的表达两两比较差异均有统计学意义（P<005）。结论重度子痫前期患者胎盘组织中TGF-β1和MMP-9表达异常，提示两者可能共同参与重度子痫前期的发生。
Abstract:
ObjectiveTo study the expression and clinical significance of transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase-9 (MMP-9) in placenta of patients with severe preeclampsia. MethodsThe expression of TGF-β1 and MMP-9 in placenta of 50 normal pregnant women and 60 cases of preeclampsia (25 cases were mild and 35 cases were severe) were analyzed by Western blot. Including 15 cases of early-onset mild preeclampsia, 10 cases of late-onset mild preeclampsia; 18 cases of early-onset severe preeclampsia and 17 cases of late-onset severe preeclampsia. ResultsThe expression of TGF-β1 was significantly increased in the stage of severe preeclampsia, and the expression of MMP-9 was significantly decreased.Compared with mild preeclampsia group and normal pregnancy group, the differences were statistically significant(P<005).The expression of TGF-β1 in placental tissue was negatively correlated with the expression of MMP-9 (P<005). The expression of TGF-β1 and MMP-9 in early-onset and late-onset group of patients with preeclampsia were compared and differences between the two were statistically significant(P<005). ConclusionThe abnormal expression of TGF-β1 and MMP-9 in placenta of patients with severe preeclampsia may be related to the occurrence of severe preeclampsia.

参考文献/References:

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更新日期/Last Update: 2017-10-25