[1]臧晓党*,谭森,李影,等.盐酸戊乙奎醚注射液预防剖宫产术中卡前列素氨丁三醇不良反应的临床观察[J].中国计划生育和妇产科,2018,(6):68-70,78.
　ZANG Xiao-dang*,TAN Sen,LI Ying,et al.Clinical effects of penehyclidine hydrochloride injection on adverse reactions caused by carboprost tromethamine in cesarean section[J].Chinese Journal of Family Planning & Gynecotokology,2018,(6):68-70,78.
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盐酸戊乙奎醚注射液预防剖宫产术中卡前列素氨丁三醇不良反应的临床观察
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年6期
页码:
68-70,78
栏目:
论著与临床
出版日期:
2018-06-25

文章信息/Info

Title:
Clinical effects of penehyclidine hydrochloride injection on adverse reactions caused by carboprost tromethamine in cesarean section
作者:
臧晓党1*; 谭森2; 李影2; 王爱菊1;  张淑红1
廊坊市第四人民医院, 1.产科；2.麻醉科
Author(s):
ZANG Xiao-dang1*;  TAN Sen2;  LI Ying2;  WANG Ai-ju1;  ZHANG Shu-hong1
1. Department of Obstetrics;2. Department of Anesthesiology, Fourth People’s Hospital of Langfang City,Langfang Hebei 065700,P.R.China
关键词:
盐酸戊乙奎醚; 卡前列素氨丁三醇; 剖宫产; 不良反应
Keywords:
penehyclidine hydrochloride;  carboprost tromethamine;  cesarean section;  adverse reactions
分类号:
R 7198
摘要:
目的观察盐酸戊乙奎醚注射液预防剖宫产术中卡前列素氨丁三醇不良反应的临床效果。方法回顾性分析2015年1月至2017年3月在廊坊市第四人民医院因宫缩乏力行剖宫产术而使用卡前列素氨丁三醇的产妇70例的临床资料，按照术中是否使用盐酸戊乙奎醚注射液将患者分为盐酸戊乙奎醚组和对照组，每组35例。两组均采用新式子宫下段剖宫产术，使用缩宫素和卡前列素氨丁三醇前盐酸戊乙奎醚组静脉注射稀释于2 mL生理盐水的盐酸戊乙奎醚05 mg，对照组则静脉注射生理盐水2 mL。观察比较两组产妇恶心、呕吐、面部潮红、胸闷憋气、血压升高、心悸等不良反应的发生情况。结果 ① 两组产妇年龄、体质量、ASA分级、孕周、术中输液量、术中出血量、手术时间等一般资料比较，差异无统计学意义（P＞005）；② 两组间各时间节点平均动脉压、心率、经皮血氧饱和度和呼吸频率相比较，差异均无统计学意义（P＞005）。③ 盐酸戊乙奎醚组恶心、呕吐、胸闷憋气的发生率明显低于对照组，差异有统计学意义（P＜005）。结论盐酸戊乙奎醚注射液可有效预防剖宫产术中卡前列素氨丁三醇所致的胃肠道和呼吸道不良反应。
Abstract:
ObjectiveTo observe the clinical effects of penehyclidine hydrochloride injection on adverse reactions caused by carboprost tromethamine in cesarean section. MethodsRetrospectively analyzed 70 cases of maternity who used cardoprost tromethamine to perform caesarean section due to uterine inertia at Fourth People’s Hospital of Langfang City from January 2015 to March 2017. Patients were divided into the penehyclidine hydrochloride group and the control group according to whether used penehyclidine hydrochloride injection, with 35 cases in each group.The patients in two groups were operated the new lower uterine segment cesarean section. Before oxytocin and carboprost tromethamine used,the patients were injected intravenous penehyclidine hydrochloride 05mg(diluted in 2 mL saline solution) in penehyclidine hydrochloride group, were injected intravenous saline solution 2 mL in control group. Nausea, vomiting, facial flush, chest tightness, high blood pressure, heart palpitations and other adverse reactions were observed and compared in the two groups. Results① The general data such as age, body quality ,grade of ASA, gestational age,intraoperative infusion quantity, intraoperative blood loss, operative time were compared in the two groups,there were no statistically significant differences (P< 005).② MAP(mean arterial pressure), HR(heart rate),SpO2(percutaneous oxygen saturation)and RR(respiratory rate）had no statistical differences（P＞005）at each time node in the two groups.③ Nausea, vomiting, chest stufly and suffocating in penehyclidine hydrochloride group were lower significantly than those in control group, the differences were statistically significant (P<005).ConclusionPenehyclidine hydrochloride injection can prevent effectively the gastrointestinal and respiratory adverse reactions caused by carboprost tromethamine in cesarean section.

参考文献/References:

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更新日期/Last Update: 2018-06-25