[1]谭森*,李影,臧晓党,等.盐酸戊乙奎醚联合地塞米松、托烷司琼预防剖宫产术中卡前列素氨丁三醇引发不良反应的效果观察[J].中国计划生育和妇产科,2018,(11):59-62.
　TAN Sen*,LI Ying,ZANG Xiao-dang,et al.Effects of penehyclidine hydrochloride combined with dexamethasone, tropisetron on adverse reactions caused by carboprost tromethamine in cesarean section[J].Chinese Journal of Family Planning & Gynecotokology,2018,(11):59-62.
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盐酸戊乙奎醚联合地塞米松、托烷司琼预防剖宫产术中卡前列素氨丁三醇引发不良反应的效果观察
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年11期
页码:
59-62
栏目:
论著与临床
出版日期:
2018-11-25

文章信息/Info

Title:
Effects of penehyclidine hydrochloride combined with dexamethasone, tropisetron on adverse reactions caused by carboprost tromethamine in cesarean section
作者:
谭森1*; 李影1; 臧晓党2; 王爱菊2; 张淑红2
廊坊市第四人民医院，1.麻醉科；2.产科
Author(s):
TAN Sen1*;  LI Ying1;  ZANG Xiao-dang2;  WANG Ai-ju2;  ZHANG Shu-hong2
1. Department of Anesthesiology;2.Department of Obstetrics, Fourth People’s Hospital of Langfang City，Langfang Hebei 065700,P.R.China
关键词:
盐酸戊乙奎醚; 地塞米松; 托烷司琼; 卡前列素氨丁三醇; 剖宫产; 不良反应
Keywords:
penehyclidine hydrochloride; dexamethasone; tropisetron; carboprost tromethamine; cesarean section; adverse reaction
分类号:
R 984
摘要:
目的观察盐酸戊乙奎醚联合其他药物预防剖宫产术中卡前列素氨丁三醇引发不良反应的效果。方法选择2014年1月至2017年3月廊坊市第四人民医院存在产后出血高危因素择期行剖宫产产妇120例，按照入院顺序随机分为对照组、观察1组及观察2组，每组40例。于胎儿娩出断脐即刻，对照组静脉注射10 mg地塞米松和5 mg托烷司琼；观察1组静脉注射10 mg地塞米松和１mg盐酸戊乙奎醚；观察2组静脉注射10 mg地塞米松、5 mg托烷司琼及1 mg盐酸戊乙奎醚。3组胎儿娩出后行卡前列素氨丁三醇250μg宫体注射。监测3组麻醉前(T0)、卡前列素氨丁三醇使用10 min 后(T1)、卡前列素氨丁三醇使用20 min 后 (T2)及手术结束时(T3)的收缩压(systolic blood pressure，SBP)、舒张压（diastolicblood pressure，DBP)、心率(heart rate，HR)及血氧饱和度(oxygen saturation，SPO2)。比较3组产妇卡前列素氨丁三醇宫体注射后恶心、呕吐、面部潮红、胸闷憋气、心悸等不良反应发生情况。结果① 3组产妇手术时间、术中输液量、术毕出血量比较，差异均无统计学意义（P＞005）；② 3组产妇T1、T2时SBP、DBP、HR 有所升高，但与T0比较，差异无统计学意义（P＞005），T3 时恢复至T0水平。3组不同时间点SPO2无明显变化。③ 观察1组和观察2组恶心呕吐Ⅱ级、Ⅲ级及面部潮红、胸闷憋气、心悸发生率明显低于对照组，观察2组恶心呕吐Ⅱ级、Ⅲ级发生率明显低于观察1组，差异均有统计学意义（P＜005)。结论盐酸戊乙奎醚联合地塞米松和托烷司琼有利于降低剖宫产手术卡前列素氨丁三醇应用引发的不良反应发生率。
Abstract:
ObjectiveTo observe the effects of penehyclidine hydrochloride combined with dexamethasone, tropisetron on adverse reactions caused by carboprost tromethamine in cesarean section.Methods120 cases of lying-in women with cesarean section who had high risk of postpartum hemorrhage in Fourth People’s Hospital of Langfang City from January 2014 to March 2017 were selected. All lying-in women were randomly divided into control group (n=40), first observation group(n=40) and second observation group(n=40) according to admission order. At the moment of fetal childbirth and rupture of umbilical cord, dexamethasone 10 mg and tropisetron 5 mg were injected intravenous in control group, dexamethasone 10 mg and penehyclidine hydrochloride １mg were injected intravenous in first observation group, dexamethasone 10 mg,tropisetron 5 mg and penehyclidine hydrochloride１mg were injected intravenous in second observation group. Carboprost tromethamine 250 μg were injected into uterus body after fetal childbirth in three groups. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and blood oxygen saturation (SPO2) before anesthesia (T0), 10 min after carboprost tromethamine used (T1), 20 min after carboprost tromethamine used (T2) and at the end of surgery (T3) were monitored in three groups.The adverse reactions such as nausea, vomiting, facial flush, chest tightness, palpitations after carboprost tromethamine injected were observed and compared in three groups.Results① The operation time, injection volume and bleeding volume among three groups showed no statistically significant difference (P＞005). ② SBP,DBP,HR at T1 and T2 increased slightly in three groups, but compared with T0，there were no statistical difference (P> 005).SBP,DBP,HR at T3 returned to the levels at T0. SPO2 at different time points had no obvious change in three groups.③ The incidences of Ⅱ, Ⅲ level of nausea and vomiting, facial blushing, chest tightness, heart palpitations in first observation group and second observation group were lower significantly than those in control group, the differences were statistically significant (P<005). The incidences of Ⅱ, Ⅲ level of nausea and vomiting in second observation group were lower significantly than those in first observation group, the differences were statistically significant (P<005).ConclusionPenehyclidine hydrochloride combined dexamethasone and tropisetron can reduce significantly the adverse reactions caused by carboprost tromethamine in cesarean section.

参考文献/References:

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[2]臧晓党*,谭森,李影,等.盐酸戊乙奎醚注射液预防剖宫产术中卡前列素氨丁三醇不良反应的临床观察[J].中国计划生育和妇产科,2018,(6):68.
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备注/Memo

备注/Memo:
廊坊市科学技术研究与发展计划（项目编号：2017013047）
更新日期/Last Update: 2018-11-25