[1]郭秋云.胎膜早破孕妇阴道分泌物中降钙素原、 C-反应蛋白、肿瘤坏死因子α、白介素6用于预测绒毛膜羊膜炎的临床价值[J].中国计划生育和妇产科,2018,(9):24-27.
　GUO Qiu-yun.Clinical value of PCT,CRP,TNF-α and IL-6 in vaginal discharge of pregnant women with premature rupture of membranes to predict chorioamnionitis[J].Chinese Journal of Family Planning & Gynecotokology,2018,(9):24-27.
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胎膜早破孕妇阴道分泌物中降钙素原、 C-反应蛋白、肿瘤坏死因子α、白介素6用于预测绒毛膜羊膜炎的临床价值
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年9期
页码:
24-27
栏目:
论著与临床
出版日期:
2018-09-25

文章信息/Info

Title:
Clinical value of PCT,CRP,TNF-α and IL-6 in vaginal discharge of pregnant women with premature rupture of membranes to predict chorioamnionitis
作者:
郭秋云
泰山医学院附属肥城医院（肥城市人民医院）产科
Author(s):
GUO Qiu-yun
Department of Obstetrics,Taishan Medical College Affiliated Feicheng Hospital (Feicheng People's Hospital),Feicheng Shandong 271600,P.R.China
关键词:
胎膜早破; 绒毛膜羊膜炎; 降钙素原; C-反应蛋白; 肿瘤坏死因子α; 白介素6
Keywords:
premature rupture of membranes;  chorioamnionitis;  procalcitonin;  C-reactive protein;  tumor necrosis factor-α;  interleukin-6
分类号:
R 714.43+3
摘要:
目的探讨胎膜早破孕妇阴道分泌物中降钙素原（procalcitonin,PCT）、C-反应蛋白(C-reactive protein，CRP)、肿瘤坏死因子α（tumor necrosis factor α,TNF-α）、白介素6（interleukin-6,IL-6）的水平在预测绒毛膜羊膜炎中的临床价值。方法选取2015年2月至2017年2月肥城市人民医院妇产科收治的胎膜早破孕妇79例为胎膜早破组，另选取同期胎膜正常孕妇60例为对照组，检测两组孕妇阴道分泌物中PCT、CRP、TNF-α、IL-6的含量，以产后对胎膜组织病理检查为金标准，分析PCT、CRP、TNF-α、IL-6在胎膜早破合并绒毛膜羊膜炎中的预测价值。结果胎膜早破组孕妇阴道分泌物中PCT、CRP、TNF-α、IL-6含量明显高于对照组，差异有统计学意义（t=78185、36147、24621、17392，P＜005）；其中胎膜早破组合并绒毛膜羊膜炎的孕妇阴道分泌物中PCT、CRP、TNF-α、IL-6含量明显高于未合并绒毛膜羊膜炎孕妇，差异有统计学意义（t=47678、27967、31001、16080，P＜005），且各指标随绒毛膜羊膜炎严重程度升高呈增加趋势（F=187127、117139、83310、98294，P＜005）；分泌物PCT、CRP、TNF-α、IL-6检测诊断曲线下面积（area under the curve,AUC)分别为0825、0756、0675、0723。结论胎膜早破合并绒毛膜羊膜炎孕妇阴道分泌物中PCT、CRP、TNF-α、IL-6含量均明显升高，其中PCT在胎膜早破后绒毛膜羊膜炎发生中的预测价值优于其它指标。
Abstract:
ObjectiveTo explore clinical value of procalcitonin (PCT), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) levels in vaginal discharge of pregnant women with premature rupture of membranes to predict chorioamnionitis. Methods79 cases of pregnant women with premature rupture of membranes treated in Taishan Medical College Affiliated Feicheng Hospital (Feicheng People's Hospital） from February 2015 to February 2017 were selected as the study objects, and another 60 cases of pregnant women with normal fetal membranes were selected as the control group. The contents of PCT, CRP, TNF-α and IL-6 in vaginal secretions were detectd, and the prognostic value of PCT, CRP, TNF-α and IL-6 in premature rupture of membranes with chorioamnionitis were analyzed using postnatal examination of fetal membranes as gold standard. ResultsThe contents of PCT, CRP, TNF-α and IL-6 in vaginal secretions of pregnant women with premature rupture of membranes were significantly higher than those of normal pregnant women, with statistically significant differences between the two groups (t=78185, 36147, 24621, 17392, P< 005), in which the levels of PCT, CRP, TNF-α and IL-6 in vaginal secretions of patients with premature rupture of membranes combined with chorioamnionitis were significantly higher than those of patients without incision of chorioamnionitis (t=47678, 27967, 31001, 16080, P<005), and the levels of these indexes increased with the severity of chorioamnionitis (F=187127, 117139, 83310, 98294, P<005). The AUC of PCT, CRP, TNF-α and IL-6 were 0825, 0756, 0675, 0723, respectively. ConclusionPCT, CRP, TNF-α and IL-6 in vaginal discharge of pregnant women with premature rupture of membranes combined with chorioamnionitis increase significantly, in which the predictive value of PCT in chorioamnionitis after premature rupture of membranes is superior to other indexes.　

参考文献/References:

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更新日期/Last Update: 2018-09-25