[1]李影*,谭森,臧晓党,等.咪达唑仑与昂丹司琼减少剖宫产术中卡前列素氨丁三醇所致不良反应的对比观察[J].中国计划生育和妇产科,2018,(9):55-58.
　LI Ying*,TAN Sen,ZANG Xiao-dang,et al.Efficacy comparison of midazolam and ondansetron on adverse reactions caused by carboprost tromethamine in cesarean section[J].Chinese Journal of Family Planning & Gynecotokology,2018,(9):55-58.
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咪达唑仑与昂丹司琼减少剖宫产术中卡前列素氨丁三醇所致不良反应的对比观察
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年9期
页码:
55-58
栏目:
论著与临床
出版日期:
2018-09-25

文章信息/Info

Title:
Efficacy comparison of midazolam and ondansetron on adverse reactions caused by carboprost tromethamine in cesarean section
作者:
李影1*; 谭森1;  臧晓党2; 王爱菊2; 张淑红2
廊坊市第四人民医院，1.麻醉科；2. 产科
Author(s):
LI Ying1*; TAN Sen1;  ZANG Xiao-dang2;  WANG Ai-ju2;  ZHANG Shu-hong2
1.Department of Anesthesiology;2.Department of Obstetrics,Fourth People’s Hospital of Langfang City，Langfang Hebei 065700,P.R.China
关键词:
咪达唑仑; 昂丹司琼; 卡前列素氨丁三醇; 不良反应; 剖宫产
Keywords:
midazolam;  ondansetron;  carboprost tromethamine;  adverse reaction;  cesarean section
分类号:
R 719.8
摘要:
目的对比观察咪达唑仑与昂丹司琼减少剖宫产术中卡前列素氨丁三醇所致不良反应的效果。方法选择2015年1月至2017年7月廊坊市第四人民医院剖宫产术中宫缩乏力产妇135例，按随机数字表法分为对照组、A组和B组，每组45例。3组均于胎儿娩出后立即行卡前列素氨丁三醇250 μg宫体注射。对照组于胎儿娩出后静脉注射生理盐水2 mL；A组于术前即刻静脉注射昂丹司琼４mg；B组于胎儿娩出后静脉注射咪达唑仑004 mg/kg。记录Ｔ0（入室后即刻）、Ｔ1（胎儿娩出后卡前列素氨丁三醇注射前）、Ｔ2（卡前列素氨丁三醇注射后5 min）、Ｔ3 (手术结束时)等时间点的收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、心率(heart rate，HR)及血氧饱和度(blood oxygen saturation，SPO2)，比较3组T1、T2、T3时的警觉与镇静评分(observer’s assessment of alertness/sedation，OAAS)。观察3组卡前列素氨丁三醇宫体注射后恶心、呕吐、胸闷憋气等不良反应发生情况。结果① 3组T2时SBP、DBP、HR增高，SPO2降低，与T1时比较差异均有统计学意义（P＜005）。但B组SBP、DBP、HR变化幅度小于对照组与A组（P＜005）。② A组和B组Ｔ2、Ｔ3时OAAS评分较T1及对照组降低，差异均有统计学意义（P＜005）。③ A组和B组恶心、呕吐、胸闷憋气发生率低于对照组，B组恶心、呕吐、胸闷憋气发生率低于A组，差异均有统计学意义（P＜005）。结论与昂丹司琼相比，咪达唑仑可明显减少卡前列素氨丁三醇所致的恶心、呕吐和胸闷憋气及血压升高、心率加快等不良反应。
Abstract:
ObjectiveTo compare the efficacy of midazolam and ondansetron on adverse reactions caused by carboprost tromethamine in cesarean section. Methods135 cases of caesarean section maternal with uterine inertia in Fourth People’s Hospital of Langfang City from January 2015 to July 2017 were divided into control group, group A and group B by random number table,with 45 cases in each group.The patients in three groups were injected carboprost tromethamine 250 μg at the moment of fetal childbirth and rupture of umbilical cord. In the control group, 2 mL of saline was injected intravenously after the fetus was delivered. In group A, 4 mg of ondansetron was injected intravenously immediately before operation. Group B received intravenous midazolam 004 mg/kg after the fetus was delivered.Systolicblood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and oxygen saturation (SPO2) at Ｔ0 (immediate after entering the operating room), Ｔ1(after fetal childbirth, before carboprost tromethamine injected), Ｔ2(5 min after carboprost tromethamine injected), T3 (at the end of operation) were recorded. Observer’s assessment of alertness/sedation(OAAS)at T1,T2,T3 were compared in three groups. The adverse reactions such as nausea, vomiting, chest tightness after carboprost tromethamine injected were observed in three groups. Results① Compared with those at T1, SBP, DBP and HR at T2 elevated significantly, SPO2 decreased significantly in three groups, and the difference was statistically significant (P<005). The changes of SBP, DBP and HR in group B were smaller than that in control group and group A (P<005).② Compared with those at T1 and in control group, OAAS at Ｔ2 and Ｔ3 decreased significantly in group A and group B, and the difference was statistically significant (P< 005).③ The adverse reactions such as nausea, vomiting, chest tightness in group A and group B were less than those in control group, the incidence rates of nausea, vomiting, chest tightness in group B were less than those in group A, the differences were statistically significant (P< 005). ConclusionCompared with ondansetron, midazolam can reduce significantly the adverse reactions such as nausea, vomiting, chest stuffiness and elevation of blood pressure, accelerated heart rate caused by carboprost tromethamine in cesarean section.

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更新日期/Last Update: 2018-09-25