[1]赵佳,何玉霞,杜利君*.四川南充地区3 762例女性高危型人乳头瘤病毒感染结果分析[J].中国计划生育和妇产科,2018,(8):94-96.
　ZHAO jia,HE Yu-xia,DU Li-jun*.Analysis of 3 762 women with high-risk HPV infection in Nanchong area, Sichuan[J].Chinese Journal of Family Planning & Gynecotokology,2018,(8):94-96.
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四川南充地区3 762例女性高危型人乳头瘤病毒感染结果分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年8期
页码:
94-96
栏目:
论著与临床
出版日期:
2018-08-25

文章信息/Info

Title:
Analysis of 3 762 women with high-risk HPV infection in Nanchong area, Sichuan
作者:
赵佳; 何玉霞; 杜利君*
南充市中心医院（川北医学院第二临床医学院）检验科
Author(s):
ZHAO jia;  HE Yu-xia;  DU Li-jun*
Laboratory,Nanchong Central Hospital(the Second Clinical Medical College of North Sichuan Medical College),Nanchong Sichuan 637000,P.R.China
关键词:
高危型人乳头瘤病毒; 亚型分布; 宫颈肿瘤; 预防和筛查
Keywords:
high-risk human papillomavirus; subtype distribution; cervical neoplasms; prevention and screening
分类号:
R 71174
摘要:
目的分析南充地区女性高危型人乳头瘤病毒（high-risk human papillomavirus,HR-HPV）感染率、亚型及其分布特点。方法收集南充市中心医院2014年7月至2017年7月门诊及体检共3 762例女性宫颈分泌物标本。采用荧光PCR法进行15种HR-HPV分型检测，并将所有受检者分为6个年龄段，对所得结果进行分析。结果3 762例受检者共检测出阳性659例，阳性率为175 %，感染以单一和双重为主，检出率最高的3种亚型依次为52型209例（317 %）、58型173例（263 %）和16型152例（231 %）；6个年龄段中，阳性率较高的是≤20岁（191 %）、51～60岁（228 %）和≥61岁（295 %）人群。结论南充地区女性HR-HPV感染以52、58、16型为主，表现出明显的地域特点。HR-HPV检测对本区域宫颈肿瘤的早期预防和筛查有指导意义。
Abstract:
ObjectiveTo analyze the infection rate,subtype and distribution of high-risk（human papillomavirus(HR-HPV) in women in Nanchong area.MethodsA total of 3 762 female cervical secretion specimens were collected in Nanchong Central Hospital from July 2014 to July 2017 for outpatient and physical examination. Fifteen HR-HPV typing tests were performed by fluorescence PCR, and all subjects were divided into 6 age groups, and the results were analyzed.ResultsA total of 659 positive samples were detected in 3 762 subjects, the positive rate was 175 %. The infections were mainly single and double. The three subtypes with the highest detection rate were HPV52 209 cases(317 %) and HPV58 173 cases(263 %) and 152 cases(231 %) of type 16; Among the 6 age groups,the higher positive rate was ≤20 years old(191 %), 51～60 years old(228 %) and ≥61 years old(295 %).ConclusionThe female HR-HPV infection in Nanchong area was mainly 52, 58 and 16 types, showing obvious regional feature. HR-HPV testing is instructive for early prevention and screening of cervical tumors in the region.

参考文献/References:

［1］TORRE L A, BRAY F, SIEGEL R L, et al. Global cancer statistics, 2012 ［J］. CA-A Cancer Journal for Clinicians, 2015, 65(2): 87-108. ［2］蒋雪梅(综述),李华,顿耀艳(审校).宫颈癌的研究新进展 ［J］现代医药卫生，2015，31（21）：3251-3253 ［3］SASLOW D, SOLOMON D, LAWSON H W, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer ［J］. Journal of Lower Genital Tract Disease, 2012, 16(3): 175-204. ［4］杨雪霞，刘健，黄春丽HPV-DNA的检测与分型诊断在宫颈癌筛查中的意义 ［J］深圳中西医结合杂志，2016，26（9）：58-59 ［5］王霞，李霞斌，李宗恒HPV 16/18在宫颈上皮内瘤变及宫颈癌中表达 ［J］中国病原生物学杂志，2017，12（2）：182-184, 188 ［6］刘玉萍，沈太敏，帅平，等成都市健康体检妇女人乳头状瘤病毒感染及基因亚型分析 ［J］实用医院临床杂志，2015，12（6）：52-54 ［7］李世宁，阮思蓓，邓正华，等泸州地区人乳头瘤病毒感染的分子流行病学研究 ［J］现代预防医学，2013，40（22）：4109-4112 ［8］邓健康，郭晓兰四川东北地区女性人乳头瘤病毒感染的型别分布 ［J］国际检验医学杂志，2014，35（4）：421-423 ［9］Clifford GM,Swith JS,Plummer M,et al.Human papilloma virus types in invasive cervical cancer worldwide:a meta-analysis ［J］.Br J Cancer,2003,88(1):63-73 ［10］姚军，李曼，钟萍，等HPV亚型感染的地域分布与宫颈病变的关系 ［J］实用妇产科杂志，2011，27（1）：34-38 ［11］LO K W, WONG Y F, CHAN M K, et al. Prevalence of human papillomavirus in cervical cancer: a multicenter study in China ［J］. International Journal of Cancer，2002, 100(3): 327-331. ［12］曾莉，郭遂群，云径平，等广州地区宫颈癌组织标本中HPV感染情况的初步分析 ［J］南方医科大学学报，2007，27（3）：399-400 ［13］杜宏，索兰草，刘红贤，等甘肃地区女性宫颈 HPV 感染的现状研究 ［J］暨南大学学报（自然科学与医学版），2015，36（1）：40-45 ［14］肖林林，赵卫卫，彭攸，等区域内HPV亚型分布特点及其与宫颈病变的关系 ［J］国际检验医学杂志，2017，38（3）：360-362, 365 ［15］Baseman JG,Koutsky LA.The epidemiology of human papillomavirus infections ［J］.J Clin Virol,2005,32（3）:S 16-S 24 ［16］SELLORS J W, MAHONY J B, KACZOROWSKI J, et al. Prevalence and predictors of human papillomavirus infection in women in Ontario, Canada ［J］. Canadian Medical Association Journal, 2000, 163(5): 503-508.

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更新日期/Last Update: 2018-08-25