[1]黄珂珂*,沈晓亚.小剂量左甲状腺素对早期妊娠合并亚临床甲状腺功能减退症患者的疗效及安全性分析[J].中国计划生育和妇产科,2019,(3):57-59,67.
 HUANG Ke-ke*,SHEN Xiao-ya.Efficacy and safety of low-dose levothyroxine in early pregnancy with subclinical hypothyroidism[J].Chinese Journal of Family Planning & Gynecotokology,2019,(3):57-59,67.
点击复制

小剂量左甲状腺素对早期妊娠合并亚临床甲状腺功能减退症患者的疗效及安全性分析
分享到:

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2019年3期
页码:
57-59,67
栏目:
论著与临床
出版日期:
2019-03-25

文章信息/Info

Title:
Efficacy and safety of low-dose levothyroxine in early pregnancy with subclinical hypothyroidism
作者:
黄珂珂1*沈晓亚2
1.210044江苏南京,东南大学附属中大医院江北院区(南京市大厂医院)内分泌科;2.210048江苏南京,南京江北人民医院妇科
Author(s):
HUANG Ke-ke1*SHEN Xiao-ya2
1. Department of Endocrinology, Zhongda Hospital Jiangbei District Affiliated of Southeast University (Dachang Hospital of Nanjing), Nanjing Jiangsu 210044,P.R.China;2. Department of Gynecology, Nanjing Jiangbei People's Hospital, Nanjing Jiangsu 210048,P
关键词:
左甲状腺素早期妊娠亚临床甲状腺功能减退症疗效安全性
Keywords:
levothyroxineearly pregnancysubclinical hypothyroidismefficacysafety
分类号:
R 714.256
摘要:
目的探讨小剂量左甲状腺素对早期妊娠合并亚临床甲状腺功能减退症患者疗效和安全性的影响。方法将2015年6月至2017年6月东南大学附属中大医院江北院区收治的早期妊娠合并亚临床甲状腺功能减退症患者124例作为研究对象,按照随机数字表法分为两组,每组62例。对照组给予常规治疗,观察组在此基础上给予小剂量左甲状腺素治疗。对比两组临床疗效、治疗前后甲状腺功能指标、并发症发生率和妊娠结局情况。结果观察组治疗有效率高于对照组(P<005);观察组治疗后促甲状腺素水平低于对照组,游离三碘甲状腺原氨酸、游离甲状腺素水平高
Abstract:
ObjectiveTo investigate the efficacy and safety of low-dose levothyroxine on the early pregnancy with subclinical hypothyroidism. Methods124 cases of early pregnancy with subclinical hypothyroidism admitted from June 2015 to June 2017 in Zhongda Hospital

参考文献/References:

[1]尹鑫,刘文,梁登辉,等.自拟健脾补肾养血安胎汤联合左甲状腺素钠片治疗孕早期先兆流产合并亚临床甲状腺功能减退症疗效观察 [J].现代中西医结合杂志,2017,26(17):1900-1902. [2]代琳,安红歌.亚临床甲状腺功能减退症对孕妇母婴结局的影响 [J].检验医学与临床,2017,14(12):1793-1795. [3]邵侃,曲伸,陈美新,等.小剂量左甲状腺素干预治疗早期妊娠合并亚临床甲状腺功能减退症的临床疗效分析 [J].中国医刊,2016,51(10):45-48. [4]张俊林.疏肝健脾温肾方联合左甲状腺素钠片治疗桥本甲状腺炎合并亚临床甲状腺功能减退48例 [J].中医研究,2017,30(2):24-26. [5]Pedrera-Zamorano JD, Roncero-Martin R, Calderon-Garcia JF, et al.Treatment of subclinical hypothyroidism does not affect bone mass as determined by dual-energy X-ray absorptiometry,peripheral quantitative computed tomography and quantitative bone ultrasound in Spanish women [J].Arch Med Sci, 2015, 11(5): 1008-1014. [6]刘晓莉.左旋甲状腺素治疗对亚临床甲状腺功能减退症孕妇血清叶酸和甲状腺功能的影响 [J].中国现代医生,2017,55(16):20-22. [7]杨雷,陈惠华,江晓容,等.妊娠早中期亚临床甲状腺功能减退对后代甲状腺功能及智力发育的影响 [J].中国计划生育和妇产科,2017,9(4):24-26, 37. [8]姚进利.妊娠合并亚临床甲状腺功能减退症的早期治疗对妊娠结局的影响 [J].中国社区医师,2017,33(15):79,81. [9]Wasniewska M, Aversa T, Salerno M, et al.Five-year prospective evaluation of thyroid function in girls with subclinical mild hypothyroidism of different etiology [J].Eur J Endocrinol, 2015, 173(6): 801-808. [10]李春仙,陈敏,李美红,等.妊娠妇女亚临床甲状腺功能减退症对妊娠结局的影响 [J].中华内分泌代谢杂志,2015,31(11):937-940. [11]刘妍,刘颖,俊梅.妊娠并发亚临床甲状腺功能减退症的影响因素及对妊娠结局的影响 [J].中国妇幼保健,2017,32(12):2553-2556. [12]蔡秀丽,刘爱萍,卢菊昌.亚临床型甲状腺功能减退症对妊娠及其结局的影响 [J].中国妇幼保健,2017,32(5):900-902. [13]张贵萍.温补脾肾法联合左甲状腺素对亚临床甲减患者甲状腺功能及血脂水平的影响 [J].现代中西医结合杂志,2017,26(12):1336-1338. [14]LIU Peng, LIU Ruidong, CHEN Xia, et al.Can levothyroxine treatment reduce urinary albumin excretion rate in patients with early type 2 diabetic nephropathy and subclinical hypothyroidism? A randomized double-blind and placebo-controlled study [J].Curr Med Res Opin, 2015, 31(12): 2233-2240. [15]GE Jin-fang, XU Ya-yun, LI Ning, et al.Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization [J].Endocr J, 2015, 62(10): 927-938. [16]刘芳,糜晓梅,杨晓琼,等.L-T4干预对妊娠早期合并亚临床甲状腺功能减退症孕妇发生早产风险的荟萃分析 [J].国际检验医学杂志,2017,38(16):2199-2201, 2204. [17]黄贤恩.左甲状腺素钠片治疗亚临床甲状腺功能减退的临床疗效及对患者血脂水平的影响 [J].现代实用医学,2017,29(4):471-473. [18]胡晓东,黄泽平.左旋甲状腺素治疗不同促甲状腺激素浓度老年亚临床甲状腺功能减退患者临床观察 [J].临床军医杂志,2017,45(5):525-527.

相似文献/References:

[1]张晋,冯慧馨.37例复发性流产患者抗心磷脂抗体的测定及分析[J].中国计划生育和妇产科,2011,(02):0.
[2]田中太,汪慧丽,李娈英,等.阴道超声可视无痛人工流产术终止早期妊娠的临床分析[J].中国计划生育和妇产科,2011,(05):0.
 TIAN Zhong-tai,WANG Hui-li,LI Luan-ying.[J].Chinese Journal of Family Planning & Gynecotokology,2011,(3):0.
[3]卢丽娟,骆志玲,雷俊华,等.超声心动图在早期妊娠胎儿心脏检查中的应用[J].中国计划生育和妇产科,2014,(03):0.
 LU Li-juan,LUO Zhi-ling,LEI Jun-hua,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(3):0.
[4]柯梅英,岑秋妹,冯亦芳,等.药物与人工流产终止早期妊娠的临床比较[J].中国计划生育和妇产科,2014,(04):0.
 KE Mei-ying,CEN Qiu-mei,FENG Yi-fang,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2014,(3):0.
[5]陈思佳,尹鹤,杨姣,等.早孕期超声观察胎儿手部的可行性分析[J].中国计划生育和妇产科,2016,(04):0.
 CHEN Si-jia,YIN He,YANG Jiao,et al.[J].Chinese Journal of Family Planning & Gynecotokology,2016,(3):0.

备注/Memo

备注/Memo:
南京市医学科技发展项目(项目编号:YKK13183)
更新日期/Last Update: 2019-03-25