[1]赵冰*,周琳,刘静,等.促性腺激素释放激素激动剂对卵巢恶性肿瘤患者化疗中生育能力保护作用的研究[J].中国计划生育和妇产科,2018,(7):10-13,27.
 ZHAO Bing*,ZHOU Lin,LIU Jing,et al.Study on the protective effect of GnRHa on fertility in patients with ovarian malignancy during chemotherapy[J].Chinese Journal of Family Planning & Gynecotokology,2018,(7):10-13,27.
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促性腺激素释放激素激动剂对卵巢恶性肿瘤患者化疗中生育能力保护作用的研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年7期
页码:
10-13,27
栏目:
论著与临床
出版日期:
2018-07-25

文章信息/Info

Title:
Study on the protective effect of GnRHa on fertility in patients with ovarian malignancy during chemotherapy
作者:
赵冰*周琳刘静贾莉
淄博市第一医院妇科
Author(s):
ZHAO Bing*ZHOU LinLIU JingJIA Li
Department of Gynecology,the First Hospital of Zibo,Zibo Shandong 255200,P.R.China
关键词:
GnRHa卵巢恶性肿瘤化疗卵巢功能
Keywords:
GnRHa ovarian malignancy chemotherapy ovarian function
分类号:
R 737.31
摘要:
目的探究促性腺激素释放激素激动剂(gonadotropin releasing hormone agonists,GnRHa)对卵巢恶性肿瘤患者化疗中生育能力的保护作用。方法选取2012年2月至2016年2月淄博市第一医院60例因卵巢恶性生殖细胞肿瘤、早期上皮性恶性肿瘤(保留生育功能)、卵巢颗粒细胞瘤需接受化疗患者,根据治疗方法的不同分为观察组和对照组,各30例。观察组采用常规化疗联合GnRHa,对照组单用常规化疗。比较两组化疗前后黄体生成素(luteinizing hormone,LH)、卵泡刺激素(follicle stimulating hormone,FSH)、雌二醇(estradiol ,E2)、血清抗穆勒氏管激素(anti-Mullerian hormone,AHM)水平、基础窦卵泡(basal antral follicle count,bAFC)变化情况;并记录月经恢复情况与妊娠情况。结果两组患者化疗疗程数(228、234)、平均疗程数[(632±153)、(629±161)]比较差异无统计学意义(P>005);两组患者在化疗期间FSH、LH水平升高,E2水平下降;化疗后3个月,观察组FSH、LH水平低于对照组,E2水平高于对照组(P<005);两组患者月经恢复时间、化疗后复发率、恢复正常月经率比较差异无统计学意义(P>005);)观察组患者自然妊娠率(625 %)高于对照组(400 %),差异有统计学意义(P<005)。结论GnRHa应用于恶性肿瘤患者化疗中,可有效保护卵巢功能,促进恢复正常月经,维持生育能力。
Abstract:
ObjectiveTo investigate the protective effect of GnRHa on the fertility of patients with ovarian malignancy during chemotherapy. MethodsFrom February 2012 to February 2016, 60 patients with malignant ovarian germ cell tumors, early epithelial malignancies (retaining fertility function), and ovarian granulosa cell tumors underwent chemotherapy in the First Hospital of Zibo were selected. According to different treatment methods, they were divided into the observation group(30 cases) and the control group(30 cases). Routine chemotherapy, GnRHa (Da Feilin) and routine chemotherapy were used respectively. The changes of luteinizing hormone(LH), follicle stimulating hormone(FSH), estradiol(E2), serum AHM and basic sinus follicular(bAFC) were compared between the two groups before and after chemotherapy, and the menstrual recovery and pregnancy were recorded. Results There was no significant differences in the number of chemotherapy courses(228, 234) and the average number of cycles[(632±153), (629±161)] between the two groups(P>005).During chemotherapy FSH and LH levels were significantly increased while E2 level decreased. Three months after chemotherapy, the levels of FSH and LH in the observation group were significantly lower than those in the control group, and E2 levels were significantly higher than those in the control group(P<005).There were no significant differences in menstrual recovery time, recurrence rate after chemotherapy, and normal menstruation rate between the two groups(P>005); The natural pregnancy rate (625 %) in the observation group was higher than that in the control group (40 %), and the difference was statistically significant(P<005).ConclusionGnRHa is used in the chemotherapy of malignant tumor patients and can effectively protect ovarian function, promote normal menstruation and maintain fertility.

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更新日期/Last Update: 2018-07-25