[1]付蕾*,朱玉林,袁景川,等.多囊卵巢综合征患者的体质量指数对助孕妊娠结局的影响[J].中国计划生育和妇产科,2018,(6):60-63.
　FU Lei*,ZHU Yu-lin,YUAN Jing-chuan,et al.Effect of body mass index in patients with polycystic ovary syndrome on fertility pregnancy outcome[J].Chinese Journal of Family Planning & Gynecotokology,2018,(6):60-63.
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多囊卵巢综合征患者的体质量指数对助孕妊娠结局的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年6期
页码:
60-63
栏目:
论著与临床
出版日期:
2018-06-25

文章信息/Info

Title:
Effect of body mass index in patients with polycystic ovary syndrome on fertility pregnancy outcome
作者:
付蕾*; 朱玉林; 袁景川; 周莉; 刘俊山; 罗红; 陶建芳; 吴晓茜; 孙梅
石家庄市第四医院生殖医学中心
Author(s):
FU Lei*;  ZHU Yu-lin;  YUAN Jing-chuan;  ZHOU Li;  LIU Jun-shan;  LUO Hong;  TAO Jian-fang;  WU Xiao-qian;  SUN Mei
Reproductive Center, Fourth Hospital of Shijiazhuang,Shijiazhuang Hebei 050000,P.R.China
关键词:
多囊卵巢综合征; 体质量指数; 辅助生殖; 妊娠结局
Keywords:
polycystic ovarian syndrome(PCOS); body mass index; assisted reproduction;  pregnancy outcome
分类号:
R 71175
摘要:
目的分析不同体质量指数（body mass index,BMI）对多囊卵巢综合征（polycystic ovarian syndrome，PCOS）患者助孕妊娠结局的影响。方法回顾性分析2012年2月至2017年3月于石家庄市第四医院生殖医学中心就诊的1 436例PCOS孕妇的临床资料，按孕妇BMI分为正常体重组（735例）、超重组（462例）以及肥胖组（239例）。经助孕治疗后比较3组基本情况、实验室及临床指标。结果超重组及肥胖组患者的卵泡刺激素值、促性腺激素用药天数及总用量、妊娠期糖尿病发生率、早产率、流产率和巨大儿出生率显著高于正常体重组（P<005）；3组接受单精子卵泡胞浆内注射/体外受精/体外成熟（intracytoplasminc sperm injection/in vitro fertilization/in vitro mataration，ICSI/IVF/IVM)助孕治疗的病例数、人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)日直径≥18 mm 的卵泡数和多胎妊娠率差异无统计学意义（P>005）；超重组及肥胖组患者的抗苗勒氏管激素值水平、卵巢敏感指数、hCG日雌激素水平、获卵数、2PN受精率、2PN卵裂率、着床率、妊娠率显著低于正常体重组（P<005）。超重组及肥胖组患者各项指标比较，差异均无统计学意义（P>005）。结论超出正常范围的BMI会对PCOS患者助孕过程及助孕结局产生一定的负面影响。超重或肥胖PCOS患者妊娠期并发症发病率高，助孕成功率低，新生儿容易出现不良结局。该类患者应合理膳食，控制体重，以提高助孕成功率，改善妊娠结局。
Abstract:
ObjectiveTo analyze the effect of different body mass index(BMI) on the pregnancy outcome in patients with polycystic ovarian syndrome (PCOS). MethodsA total of 1 436 pregnant women with PCOS who visited the Reproductive Medicine Center of the Fourth Hospital of Shijiazhuang from February 2012 to March 2017 were retrospectively analyzed and divided into normal weight group(735 cases), overweight group(462 cases) and obesity group(239 cases) according to their pre-pregnancy BMI. After adjuvant therapy, basic cases,laboratory and clinical indicators of the three groups were compared. ResultsThe FSH value, the days of Gn treatment and the total dosage, the incidence of gestational diabetes mellitus, preterm birth rate, miscarriage rate and macrosomia in overweight and obesity groups were significantly higher than those in normal weight group (P<005). There were no significant differences among the three groups in the number of IVF / ICSI / IVM assisted pregnancies, the number of follicles at day 18 of hCG and multiple pregnancy rates(P> 005). The levels of AMH, OSI, hCG, number of oocytes retrieved, 2PN fertilization rate and 2PN cleavage rate in overweight and obesity group were significantly lower than those in normal body weight group(P<005). There was no significant differences in data between the overweight and obesity groups(P>005). ConclusionBMI beyond the normal range will have a negative impact on pregnancy-assisted pregnancy and pregnancy outcomes in patients with PCOS. Overweight or obese patients with PCOS have a high incidence of complications during pregnancy and low success rate of pregnancy. Such patients should have a reasonable diet, weight control, in order to improve the success rate of pregnancy and pregnancy outcomes.

参考文献/References:

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备注/Memo

备注/Memo:
河北省卫生厅医学科学研究重点课题资助项目（项目编号：ZD20140024）
更新日期/Last Update: 2018-06-25