[1]倪丹,刘雨生*,刘程,等.高龄患者两种体外受精方案自身病例对照与 经济学分析[J].中国计划生育和妇产科,2018,(4):73-77.
 NI Dan,LIU Yu-sheng*,LIU Cheng,et al.Self-control and economic analysis of two types of IVF in elderly patients[J].Chinese Journal of Family Planning & Gynecotokology,2018,(4):73-77.
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高龄患者两种体外受精方案自身病例对照与 经济学分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年4期
页码:
73-77
栏目:
论著与临床
出版日期:
2018-04-25

文章信息/Info

Title:
Self-control and economic analysis of two types of IVF in elderly patients
作者:
倪丹刘雨生*刘程吴莉季静娟童先宏
安徽医科大学附属省立医院生殖中心
Author(s):
NI DanLIU Yu-sheng*LIU ChengWU LiJI Jing-juanTONG Xian-hong
Reproductive Medicine Center,Anhui Provincial Hospital,Hefei Anhui 230001,P.R.China
关键词:
卵巢储备功能下降双刺激方案高孕激素方案成本-效益分析
Keywords:
diminished ovarian reservedouble stimulations protocolprogestin primed ovarian stimulationcost-effectiveness
分类号:
R 7116
摘要:
目的探讨高龄卵巢储备功能下降(diminished ovarian reserve,DOR)患者行双刺激方案失败后1年内改行高孕激素方案助孕结局的自身对照与经济学分析。方法选择 2014年1月至2017年1月在安徽医科大学附属省立医院生殖中心接受常规体外受精/卵胞浆内单精子注射技术治疗的高龄DOR患者41例为研究对象,均于双刺激方案移植失败后1年之内改行高孕激素下超促排卵 (progestin-primed ovarian stimulation,PPOS)方案,分别记为双刺激方案组和PPOS方案组。结果两组年龄、不孕年限、基础卵泡生成激素、黄体生成激素、雌二醇水平及基础窦卵泡数差异无统计学意义(P>005);双刺激方案组促排天数、治疗总费用、促排药物费较PPOS方案组高且差异均有统计学意义(P<005);双刺激方案组平均促性腺激素用量、获卵数、2PN数、可利用胚胎数大于PPOS方案组,优质胚胎数少于PPOS 方案组,但差异均无统计学意义(P>005)。PPOS方案组周期取消率、可利用胚胎率、生化妊娠率、临床妊娠率大于双刺激方案组,其获卵率、流产率小于双刺激方案组,差异均无统计学意义(P>005),其优质胚胎率大于双刺激方案组且差异有统计学意义(P<005)。结论PPOS方案相对于双刺激方案能提高优质胚胎率,获取更好的妊娠结局,缩短治疗时间,有更高的经济学效益,高龄DOR患者可优先选择。
Abstract:
ObjectiveAnalyze self-control and cost-effectiveness of two protocols in elderly patients with diminished ovarian reserve(DOR) within a year,after the failure of the freze-thaw embryo transfer in double stimulations protocol ovulation induction transfer

参考文献/References:

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备注/Memo

备注/Memo:
国家自然科学基金项目(项目编号:81370757);安徽省自然科学基金(项目编号:1608085MH202)
更新日期/Last Update: 2018-04-25