[1]黄海霞*,何克静,蔡琳,等.艾滋病阳性孕妇应用三联抗病毒药物治疗的妊娠结局研究[J].中国计划生育和妇产科,2018,(12):64-66,72.
　HUANG Hai-xia*,HE Ke-jing,CAI Lin,et al.A retrospective study of pregnancy outcomes of HIV infected women treated by three combined high efficient antiretroviral drugs[J].Chinese Journal of Family Planning & Gynecotokology,2018,(12):64-66,72.
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艾滋病阳性孕妇应用三联抗病毒药物治疗的妊娠结局研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年12期
页码:
64-66,72
栏目:
论著与临床
出版日期:
2018-12-25

文章信息/Info

Title:
A retrospective study of pregnancy outcomes of HIV infected women treated by three combined high efficient antiretroviral drugs
作者:
黄海霞1*; 何克静2; 蔡琳2; 祝昭惠2; 赵萍2
1.400000重庆，重庆市公共卫生医疗救治中心妇产科；2. 610066四川成都，成都市公共卫生临床医疗中心
Author(s):
HUANG Hai-xia1*;  HE Ke-jing2;  CAI Lin2;  ZHU Zhao-hui2;  ZHAO Ping2
1.Department of Gynecology & Obstetrics, Chongqing Public Health & Medical Center, Chongqing 400000, P.R.China；2. Chengdu Public Health & Medical Center，Chengdu Sichuan 610066，P.R.China
关键词:
艾滋病; 母婴传播; 三联抗病毒治疗; 妊娠; 病毒载量
Keywords:
HIV;  mother-to-fetus transmission;  three-combined antivirus therapy;  pregnancy;  viral load
分类号:
R 714.251
摘要:
目的观察齐多夫定（zidovudine，AZT）＋拉米夫定（lamivudine，3 TC）＋克力芝（lopinavir and ritonavir tablets，LPV/r）三联抗病毒方案用于预防艾滋病母婴传播的临床效果。 方法收集2013~2015年在成都市公共卫生临床医疗中心接受AZT＋3 TC＋LPV/r方案进行艾滋病母婴阻断的人类免疫缺陷病毒（human immunodeficiency virus，HIV）阳性孕产妇病历记录，对其用药情况、病毒载量监测和CD 4+T淋巴细胞计数结果与其他妊娠结局指标进行描述性统计分析。 结果318例患者中分娩194例（610 %），其中剖宫产152例（784 %）；平均产前用药时间（245±62）周，中途中断服药比例为366 %（71/194）；产前病毒载量（012±004）lg copies/mL，比服药前（398±065）lg copies/mL显著下降（P<005）；CD 4+T淋巴细胞计数用药后（50413±18746）/mm3较用药前（38459±19265）/mm3显著升高（P<005）；新生儿追踪至18月龄经HIV抗体检测确诊发生感染3例（152 %）。 结论艾滋病母婴阻断有赖于早期系统化的综合干预措施，通过现有艾滋病母婴阻断项目的支持，及时对筛查阳性孕妇实施三联抗病毒治疗，能够有效预防母婴传播和减少艾滋病母婴危害。
Abstract:
ObjectiveTo analyze the clinical effects of three-combined high efficient antiretroviral therapy (HAART) for preventing mother-to-fetus transmission of HIV. MethodsWith the 3-combined HAART of AZT+3TC+LPV/r adopting to prevent transmission of HIV infected women during 2013~2015 in Chengdu Public Health & Medical Center, we made a retrospective study to compare the basic pregnancy outcome indicators, and the plasma HIV load and the number of CD4+ T lymphocytes were detected and compared at treatment beginning with a week ahead laboring. ResultsAmong the 318 patients, the ratio of pregnancy to delivery was 610 % (194/318), and the rate of caesarean section was 784 % (152/194). The average prenatal drug use time was (245 ± 62) weeks, and the proportion of patients who interrupted the treatment was 366 % (71/194);the viral load before laboring was (012±004)lg copies/mL, which obviously lower than that before using anti-virus drugs (398±065）lg copies/mL(P<005), and the CD4+ T-lymphocyte count was significantly higher than before treatment (P<005). The HIV virus infection rate of new-born was 152 % (3/197) with the tracing duration till 18 months after laboring. ConclusionIt is depended the early continued comprehensive intervention of anti-virus in blocking mother-to-fetus transmission of HIV ,and the 3-combined HAART of AZT+3 TC+LPV/r was efficiency to be used with the women who were found HIV positive during screening of pregnancy.

参考文献/References:

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备注/Memo

备注/Memo:
四川省卫生计生科研基金项目（项目编号: 16PJ082）
更新日期/Last Update: 2018-12-25