[1]马斌*,刘晓丽,王艺璇,等.三维能量多普勒超声定量监测妊娠期高血压疾病患者胎盘血流灌注的研究[J].中国计划生育和妇产科,2018,(9):48-51.
 MA Bin*,LIU Xiao-li,WANG Yi-xuan,et al.Quantitative monitoring of placental perfusion in patients with hypertensive disorder complicating pregnancy by three-dimensional power Doppler ultrasonography[J].Chinese Journal of Family Planning & Gynecotokology,2018,(9):48-51.
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三维能量多普勒超声定量监测妊娠期高血压疾病患者胎盘血流灌注的研究
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年9期
页码:
48-51
栏目:
论著与临床
出版日期:
2018-09-25

文章信息/Info

Title:
Quantitative monitoring of placental perfusion in patients with hypertensive disorder complicating pregnancy by three-dimensional power Doppler ultrasonography
作者:
马斌*刘晓丽王艺璇王健冉婕
甘肃省妇幼保健院功能检查科
Author(s):
MA Bin*LIU Xiao-liWANG Yi-xuanWANG JianRAN Jie
Department of Functional Examination,Gansu Provincial Maternity and Child-care Hospital, Lanzhou Gansu 730050,P.R.China
关键词:
三维能量多普勒超声妊娠期高血压疾病胎盘血流灌注
Keywords:
three-dimensional power Doppler ultrasound hypertensive disorder complicating pregnancy placenta blood perfusion
分类号:
R 71424+6
摘要:
目的评价三维能量多普勒超声及其定量参数在妊娠期高血压疾病患者胎盘血流灌注监测中的价值。方法选择2016年1月至2017年1月在甘肃省妇幼保健院诊断为妊娠期高血压疾病的200例单胎孕妇为研究组,将其分为轻度子痫前期组(100例)、重度子痫前期组(100例),选择同期正常单胎孕妇200例为对照组。测算胎盘三维能量多普勒指数,包括血管化指数(vascularization index,VI)、血流指数(flow index,FI)、血管化-血流指数(vascularization flow index,VFI),并与孕妇子宫动脉、胎儿脐动脉、大脑中动脉的血流参数作相关分析。结果3组孕妇胎盘VI、FI及VFI比较,差异有统计学意义(P<005),重度子痫前期组和对照组、轻度子痫前期组孕妇脐动脉收缩末期峰值/舒张末期峰值(S/D)、双侧子宫动脉搏动指数(pulsatility index,PI)以及大脑中动脉PI比较,差异有统计学意义(P<005),但轻度子痫前期组和对照组比较,差异无统计学意义(P>005)。相关性分析发现3组胎盘VI、FI、VFI与脐动脉、子宫动脉、大脑中动脉血流指数相关,且胎盘VI、FI、VFI与孕龄呈明显正相关。结论三维能量多普勒超声可定量分析前壁胎盘血流灌注情况,为产前诊断妊娠期高血压疾病患者胎盘血流灌注评估提供量化依据。
Abstract:
ObjectiveTo evaluate the value of three-dimensional power Doppler ultrasound and its quantitative parameters in the monitoring of placental perfusion in patients with hypertensive disorder complicating pregnancy. Methods200 cases of singleton pregnant women diagnosed as hypertensive disorder complicating pregnancy in Gansu Provincial Maternity and Child-care Hospital from January 2016 to January 2017 were selected as the study group, and they were divided into mild preeclampsia group (100 cases) and severe preeclampsia group (100 cases), 200 normal pregnant women with single birth were selected as the control group.The three dimensional power Doppler indexes of the placenta were measured, including the vascularization index (VI), the flow index (FI), the vascularization flow index (VFI), and analyzed its correlation with blood flow parameters of the uterine artery,fetal umbilical artery and middle cerebral artery. ResultsThere were significant differences in the placental VI, FI and VFI between the three groups (P<005). The umbilical artery S/D, bilateral uterine artery PI and middle cerebral artery PI of severe preeclampsia group had significant difference with those of control group and mild preeclampsia group(P<005). However, there was no significant difference between the mild preeclampsia group and the control group (P>005). Correlation analysis found that placental VI, FI, VFI of the three groups had correlation with blood flow indexes of umbilical artery, uterine artery, middle cerebral artery,and placental VI, FI, VFI and gestational age were significantly positively correlated.ConclusionThree-dimensional power Doppler ultrasound can quantitatively analyze the blood flow perfusion of placenta in the anterior wall, and provide a quantitative basis for the prenatal diagnosis of placental perfusion in patients with hypertensive disorder complicating pregnancy.

参考文献/References:

[1]杨瑞琦,张嘉玲,朱崇磊,等应用三维多普勒超声定量测量胎盘对高血压孕妇胎儿状态的评估 [J]中华医学杂志,2015,95(31):2551-2553 [2]张彦华,林海英,高宇三维能量多普勒超声联合孕妇血清中TNF-α检测妊娠期高血压疾病的研究 [J]中国妇幼保健,2015,30(17):2818-2820 [3]张彦华,李冬梅,蔡博宇,等子痫前期三维能量多普勒超声和产后胎盘中MMP-2及TIMP-2的关系 [J]中国妇幼保健,2015,30(19):3146-3148 [4]韩磊,高燕华,王珍芳,等三维能量多普勒超声对晚孕期胎盘植入的诊断价值 [J]临床与病理杂志,2016,36(10):1616-1619 [5]LU M-d, YIN X-y, WAN G-s, et al Quantitative assessment of power Doppler mapping in the detection of renal allograft complications [J]. J Clin Ultrasound, 1999, 27(6): 319-323. [6]厉进,雷慧,范雪梅妊高征孕妇髂内动脉血流与胎盘病理学改变的相关性分析 [J]中国超声医学杂志,2016,32(7):667-669 [7]叶海琼,傅晓冬妊娠期高血压疾病孕妇胎盘小动脉平滑肌大电导钙激活钾通道表达水平的定量测定 [J]重庆医学,2015,44(30):4229-4231 [8]安景,白睿妊娠期高血压患者子宫动脉及胎儿脐动脉血流动力学研究 [J]海南医学院学报,2017,23(2):152-154 [9]Guntupalli KK, Karnad DR, Bandi V, et al. Critical illness in pregnancy: part II: common medical conditions complicating pregnancy and puerperium [J]. Chest, 2015, 148 (5): 1333-1345. [10]尹维,王建华妊娠期高血压合并胎儿宫内窘迫的胎儿大脑中动脉血流特征分析及其与缺氧的相关性 [J]海南医学院学报,2017,23(1): 131-134,138 [11]陆冰,邓学东超声对单脐动脉胎儿的围产期诊断价值 [J]中华医学超声杂志(电子版),2012,9(4):310-312 [12]李天刚,杨磊,王艺璇,等胎儿脐动脉及大脑中动脉血流参数及其比值在诊断胎儿宫内缺氧中的价值 [J]临床超声医学杂志,2013,15(5):311-314 [13]崔世红,李园园,吴娟,等脂联素与脐动脉超声血流指数预测重度子痫前期围产儿结局 [J]中华围产医学杂志,2016,19(5):390-395 [14]蒋瑜,杨太珠不同侧脐动脉缺失对胎儿先天畸形的影响 [J].中国超声医学杂志,2013,29(6):536-539 [15]陈清华,陈华娟,彭软单绒毛膜双胎合并脐动脉反向灌注序列的预后影响因素 [J].中山大学学报(医学科学版),2017,38(3):386-389 [16]吴静,赵凯英,林玉涓,等胎儿脐动脉和大脑中动脉及脐静脉导管血流阻力指标对妊高征患者胎儿宫内窘迫的预测价值 [J]广东医学,2013,34(16):2551-2553 [17]段灵敏,郭燕丽,邓凤莲,等产前超声诊断胎儿单脐动脉 [J].中国医学影像学杂志,2014,22(4):278-281 [18]胥卉苹,兰海,刘蓉超声测定胎儿脐动脉血流诊断胎儿窘迫的临床研究 [J]西南国防医药,2015,25(7):781-782 [19]陈肖侠,解丽梅超声诊断双胎妊娠并单脐动脉胎儿异常分析 [J]中国医科大学学报,2013,42(5):451-453 [20]钟惟娜,邓学东,殷林亮单脐动脉胎儿伴发先天异常的产前超声诊断分析 [J]中华医学超声杂志(电子版),2016,13(8):598-602 [21]许雅娟,李蕾,薛萍胎儿单脐动脉与染色体关系的临床调查 [J]中国妇幼保健,2013,28(6):974-975 [22]吴娟,栗河舟,王铭,等多普勒超声监测心律失常胎儿脐动脉、静脉导管血流频谱的研究 [J]中华超声影像学杂志,2014,23(10):861-864 [23]童文静,赵博文,潘美,等超声心动图对单纯性单脐动脉胎儿心功能的定量评价 [J]中国超声医学杂志,2012,28(11):1033-1036 [24]杨健安,沈逸辛,陈晓飞,等胎儿三尖瓣反流与脐动脉及大脑中动脉超声血流频谱的相关性分析 [J]临床超声医学杂志,2014,16(1):27-29 [25]Mesquita FS, Ramos RS, Pugliesi G, et al. The receptive endometrial transcriptomic signature indicates an earlier shift from proliferation to metabolism at early diestrus in the cow [J]. Biol Reprod, 2015, 93(2): 52.

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备注/Memo

备注/Memo:
甘肃省卫生行业科研计划(项目编号:GSWSKY2016-28)
更新日期/Last Update: 2018-09-25