[1]陈柱,郭艳霞,张民伟*.妊娠期高脂血症性急性胰腺炎临床分析[J].中国计划生育和妇产科,2018,(12):34-36.
　CHEN Zhu,GUO Yan-xia,ZHANG Min-wei*.Clinical analysis of hyperlipidemic acute pancreatitis in pregnancy[J].Chinese Journal of Family Planning & Gynecotokology,2018,(12):34-36.
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妊娠期高脂血症性急性胰腺炎临床分析
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年12期
页码:
34-36
栏目:
论著与临床
出版日期:
2018-12-25

文章信息/Info

Title:
Clinical analysis of hyperlipidemic acute pancreatitis in pregnancy
作者:
陈柱; 郭艳霞; 张民伟*
厦门大学附属第一医院重症医学科
Author(s):
CHEN Zhu; GUO Yan-xia; ZHANG Min-wei*
Department of Critical Care Medicine,The First Affiliated Hospital of Xiamen University,Xiamen Fujian 361003，P.R.China
关键词:
高脂血症; 急性胰腺炎; 妊娠; 血浆置换; 血液净化
Keywords:
hyperlipidemia; acute pancreatitis; pregnancy; plasma exchange; blood purification
分类号:
R 4595
摘要:
目的探讨妊娠期高脂血症性急性胰腺炎（hyperlipidemic acute pancreatitis,HLAP）的临床特点及血浆置换联合血液净化治疗疗效。方法对2013年12月至2017年2月厦门大学附属第一医院收治的11例妊娠期HLAP患者的临床资料进行回顾性分析。结果患者平均年龄273岁，妊娠中期1例，晚期10例，重症患者4例，6例患者行血浆置换联合血液净化治疗。中上腹痛为首发症状，主要合并症：胸腔积液，肺不张；重症患者突出特点：腹腔广泛渗液。血浆置换联合血液净化快速降低血甘油三脂、胆固醇、心率及呼吸频率（P<005），但对白细胞、血小板影响不明显（P>005）。结论妊娠期HLAP多发于妊娠晚期（909 %），重症患者占比364 %。血浆置换联合血液净化能快速有效降低血脂水平，临床疗效确切。妊娠期积极防治高脂血症有重要意义。
Abstract:
ObjectiveTo discuss the clinical features of hyperlipid acute pancreatitis(HLAP) in pregnancy and the therapeutic effect of plasma exchange combined with blood purification.MethodsThe clinical data of 11 cases of HLAP in pregnancy treated by The First Affiliated Hospital of Xiamen University were analyzed retrospectively. ResultsThe average age of the patients was 273 years, 1 case in the middle of pregnancy, 10 cases in the late stage. In 4 cases of severe patients, 6 patients underwent plasma exchange combined with blood purification. Abdominal pain was the first symptom, mainly complications: pleural effusion, pulmonary atelectasis. Prominent features: extensive peritoneal fluid penetration. Plasma exchange combined with blood purification can rapidly reduce triglycerides, cholesterol and lower heart rate and respiration rate (P<005), but no significant effect on white blood cells and platelets (P> 005). ConclusionHLAP is more common in late pregnancy(909 %) and 364 % in severe cases. Plasma exchange combined with blood purification can effectively reduce blood lipid level and clinical efficacy. It is important to actively prevent hyperlipidemia during pregnancy.

参考文献/References:

［1］刘雯，苗佳，王佑娟餐后高脂血症临床研究进展 ［J］.华西医学,2017,32（3）:465-470. ［2］Carr R A, Rejowski B J, Cote G A, et al.Systematic review of hypertriglyceridemia-induced acute pancreatitis:A more virulent etiology？ ［J］.Pancreatology,2016,16:469-476. ［3］中华医学会外科学分会胰腺外科学组. 急性胰腺炎诊治指南（2014版）［J］. 中华消化外科杂志,2015,1(14):1-4. ［4］诸骏仁, 高润霖, 赵水平, 等. 中国成人血脂异常防治指南(2016年修订版) ［J］. 中国循环杂志, 2016，31(10): 937-953. ［5］Chang YT, Chang MC, Tung CC, et al. Distinctive roles of unsaturated and saturated fatty acids in hyperlipidemic pancreatitis ［J］. World J Gastroenterology, 2015, 14 (32):9534-9543. ［6］王唯一，陈平，袁耀宗．钙离子在急性胰腺炎发病机制中的作用［J］. 国际消化病杂志,2016,36（1）:46-49. ［7］张帆，郭强，张渊智．高脂血症、微循环障碍与急性胰腺炎关系的探讨［J］. 胃肠病学和肝病学杂志,2011,20（3）：275-278. ［8］STEFANUTTI C，LABHADIA G，MOＲOZZI C. Severe hypertriglyceridemia－related acute pancreatitis［J］．Ther Apher Dial,2013,17 (4): 463-464. ［9］黄晓丽, 王国品, 王平等. 不同发病原因急性胰腺炎严重程度及并发症、死亡率的比较［J］. 世界华人消化杂志，2014,22（27）: 4172-4176. ［10］杨东亮,卢华东,吕德超,等.妊娠期急性胰腺炎临床分析 ［J］.肝胆外科杂志,2016,24(3):221-223. ［11］张发钦,林燕.妊娠期不同分级急性胰腺炎患者的临床特点及预后分析 ［J］.中国全科医学,2015,18 (33):4122-4125. ［12］毕晓艳.高脂血症相关性急性胰腺炎的临床分析 ［J］.当代医学,2016,22 (9):97-98.

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更新日期/Last Update: 2018-12-25