[1]詹桃桃,吴丽敏*,栾红兵,等.丹红注射液对反复种植失败患者冻胚移植妊娠结局的影响[J].中国计划生育和妇产科,2018,(10):26-29.
　ZHAN Tao-tao,WU Li-min*,LUAN Hong-bing,et al.Effect of Danhong injection on the outcome of frozen embryo transfer in patients with recurrent implantation failure[J].Chinese Journal of Family Planning & Gynecotokology,2018,(10):26-29.
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丹红注射液对反复种植失败患者冻胚移植妊娠结局的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2018年10期
页码:
26-29
栏目:
论著与临床
出版日期:
2018-10-25

文章信息/Info

Title:
Effect of Danhong injection on the outcome of frozen embryo transfer in patients with recurrent implantation failure
作者:
詹桃桃1; 2; 吴丽敏2*; 栾红兵2; 刘芬1; 2; 刘雨生2; 童先宏2
1.安徽中医药大学研究生院；2.中国科学技术大学附属第一医院（安徽省立医院）生殖中心
Author(s):
ZHAN Tao-tao1; 2;  WU Li-min2*;  LUAN Hong-bing2;  LIU Fen1; 2;  LIU Yu-sheng2;  TONG Xian-hong2
1. Graduate School of Anhui University of Traditional Chinese Medicine； 2.Reproductive Center, First Affiliated Hospital of University of Science & Technology of China (Anhui Provincial Hospital)，Hefei Anhui 230001，P.R.China
关键词:
丹红注射液; 低分子肝素; 反复种植失败; 活血化瘀; 抗凝治疗
Keywords:
Danhong injection;  low molecular weight heparin;  repeated implant failure;  promote blood circulation;  anticoagulant therapy
分类号:
R 711.6
摘要:
目的探讨对反复种植失败（recurrent implantation failure, RIF）患者应用丹红注射液配合西医常规体外受精-胚胎移植（in vitro fertilization-embryo transfer，IVF-ET）助孕治疗的临床效果。方法选取 2015年1月至2017年8月在中国科学技术大学附属第一医院（安徽省立医院）就诊、拟行冻融胚胎移植（frozen embryo transfer，FET）患者 421例，分为对照组（A组，128例）、RIF常规治疗组（B组，128例）、低分子肝素组（C组，132例）及丹红注射液组（D组，33例）。比较4组患者FET率、生化妊娠率、临床妊娠率、早期流产率、活产率。结果4组患者年龄、不孕年限、移植数目、基础性激素水平、内膜、本周期移植优质胚胎等方面比较差异均无统计学意义（P>005）。C、D组与A组种植率、生化妊娠率、临床妊娠率、早期流产率、活产率比较，差异无统计学意义（P>005）；D组与B组种植率（2759 % vs 2108 %）、生化妊娠率（4242 % vs 3438 %）、临床妊娠率（3939 % vs 3203 %）、活产率（3939 % vs 2578 %）比较差异有统计学意义（P<005）；D组与C组种植率、生化妊娠率、临床妊娠率、早期流产率、活产率比较，差异无统计学意义（P>005）。结论丹红注射液与低分子肝素均能有效改善RIF患者再次助孕治疗后的妊娠结局，提高临床妊娠率、生化妊娠率、种植率、活产率。丹红注射液具有与低分子肝素相类似的作用，丹红注射液配合西医常规FET，可有效改善RIF患者妊娠结局。
Abstract:
ObjectiveTo explore the clinical application of Danhong injection combined with conventional in vitro fertilization-embryo transfer(IVF-ET) pregnancy aid in the treatment of repeated implant failure (RIF). MethodsFrom January 2015 to August 2017, 421 patients planned to be treated by frozen embryo transfer (FET) in First Affiliated Hospital of University of Science & Technology of China (Anhui Provincial Hospital) were enrolled. They were divided into control group (group A, 128 cases), RIF conventional treatment group (group B, 128 cases), low molecular weight heparin group (group C, 132 cases) and Danhong injection group (group D, 33 cases).The implantation rate, biochemical pregnancy rate, clinical pregnancy rate, early abortion rate, and live birth rate of the four groups were compared. ResultsThere were no significant differences in age, infertility years, number of transplants, basal sex hormone levels, endometrium, and high quality embryos transplanted between the four groups (P>005). There was no significant difference in the implantation rate, biochemical pregnancy rate, clinical pregnancy rate, early abortion rate and live birth rate when group C and group D compared with group A(P>005). There were significant differences in the implantation rate(2759 % vs 2108%), biochemical pregnancy rate(4242 % vs 3438 %), clinical pregnancy rate(3939 % vs 3203 %) and live birth rate (3939 % vs 2578 %) between group D and group B (P<005). There was no significant difference in the implantation rate, biochemical pregnancy rate, clinical pregnancy rate, early abortion rate and live birth rate between group D and group C (P>005). ConclusionBoth Danhong injection and low molecular weight heparin can effectively improve the pregnancy outcome after retreatment of RIF patients, and improve the clinical pregnancy rate, biochemical pregnancy rate, implantation rate and live birth rate. Danhong injection has a similar effect to low molecular weight heparin. Danhong injection combined with Western medicine conventional FET can effectively improve the pregnancy outcome of patients with RIF.

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备注/Memo

备注/Memo:
国家自然科学基金项目资助（项目编号：81373671，81673811）
更新日期/Last Update: 2018-10-25