[1]潘玥*,葛会生,陈红.妊娠合并轻型地中海贫血补铁治疗的临床探讨[J].中国计划生育和妇产科,2019,(6):56-59.
　PAN Yue*,GE Hui-sheng,CHEN Hong.A clinical study of iron supplementation in pregnant women with mild thalassemia[J].Chinese Journal of Family Planning & Gynecotokology,2019,(6):56-59.
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妊娠合并轻型地中海贫血补铁治疗的临床探讨
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2019年6期
页码:
56-59
栏目:
论著与临床
出版日期:
2019-06-25

文章信息/Info

Title:
A clinical study of iron supplementation in pregnant women with mild thalassemia
作者:
潘玥1*; 葛会生1; 陈红2
1.成都市妇女儿童中心医院产科 2.成都中医药大学附属医院产科
Author(s):
PAN Yue1*; GE Hui-sheng1; CHEN Hong2
1.Department of Obstetrics, Chengdu Women's & Children's Central Hospital;2.Department of Obstetrics,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 610041，P.R.China
关键词:
地中海贫血; 血红蛋白; 血清铁蛋白; 妊娠结局
Keywords:
thalassemia;  hemoglobin;  serum ferritin;  pregnancy outcomes
分类号:
R 714.254
摘要:
目的探讨妊娠合并轻型地中海贫血补铁治疗的必要性和治疗时机。方法选取成都市妇女儿童中心医院2017年1月至2018年8月住院分娩的369例轻型地中海贫血孕妇，随机分为3组，A组（91例）孕期不予补铁治疗，B组（108例）建卡排除铁过载后即口服铁剂治疗，C组（170例）根据孕期血清铁蛋白(serum ferritin, SF）水平，低于30 μg/L时开始补铁治疗。比较3组患者孕期的血红蛋白(hemoglobin, Hb)、SF水平变化及妊娠结局。结果① 3组患者孕期Hb和SF均有下降，其中A组患者孕期Hb水平下降（1259±402）g/L，SF水平下降（2311±954）μg/L，明显高于B、C组，差异有统计学意义(P<005)。② 3组患者剖宫产率、产后出血量、新生儿出生体重及1 min Apgar评分，A组与B、C组比较，差异有统计学意义(P<005)，B、C两组间比较，差异无统计学意义(P>005)。结论轻型地中海贫血孕妇孕期可能存在SF减少并加重其贫血程度，增加不良妊娠结局。需动态监测SF，适时补铁治疗，以改善妊娠结局。
Abstract:
ObjectiveTo explore the necessity and timing of iron supplementation treatment in pregnancy with mild thalassemia. MethodsA total of 369 pregnant women with mild thalassemia who were hospitalized from January 2017 to August 2018 in Chengdu Women' s & Children's Central Hospital were randomly divided into three groups. Group A （91 cases） was not treated with iron supplementation during pregnancy, and group B （108 cases） was given iron supplementation when establishing pregnancy file and after removing iron overload. Group C （170 cases） according to the level of serum ferritin(SF) during pregnancy, less than 30 μg/L began to give iron supplementation. The level of hemoglobin (Hb), SF and pregnancy outcomes were compared among the three groups. Results① The levels of Hb and SF decreased in the three groups. The Hb level in the group A decreased (1259±402) g/L and the SF level decreased (2311±954) μg/L, which was significantly higher than that in the B and C groups. The difference was statistically significant (P<005).② Comparing the cesarean section rate, postpartum hemorrhage, neonatal birth weight and 1-minute Apgar score in the three groups, there was significant difference between group A and group B or group C. There was no significant difference between group B and group C (P>005). ConclusionPregnant women with mild thalassemia may have SF reduction during pregnancy and increase their anemia, increasing adverse pregnancy outcomes. Dynamic monitoring of SF and timely iron supplementation are needed to improve pregnancy outcomes.

参考文献/References:

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更新日期/Last Update: 2019-06-25