[1]张群*,陈燕婷.妊娠期高血压对慢性乙型肝炎孕妇妊娠结局及 新生儿的影响及其影响因素分析[J].中国计划生育和妇产科,2020,(7):80-83.
　ZHANG Qun*,CHEN Yanting.Effect and influencing factors of hypertension on pregnancy outcomes and newborns in chronic hepatitis B patients[J].Chinese Journal of Family Planning & Gynecotokology,2020,(7):80-83.
点击复制

妊娠期高血压对慢性乙型肝炎孕妇妊娠结局及 新生儿的影响及其影响因素分析
分享到：

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2020年7期
页码:
80-83
栏目:
妇科产科热点研究
出版日期:
2020-07-25

文章信息/Info

Title:
Effect and influencing factors of hypertension on pregnancy outcomes and newborns in chronic hepatitis B patients
作者:
张群*; 陈燕婷
三水区人民医院产科
Author(s):
ZHANG Qun*; CHEN Yanting
Department of Obstetrics,Sanshui District People’s Hospital,Foshan Guangdong 528100,P.R.China
关键词:
妊娠期高血压; 慢性乙型肝炎; 妊娠结局; 新生儿结局; 影响因素
Keywords:
blood pressure; chronic hepatitis B; pregnancy outcome; neonatal outcome;  influencing factors
分类号:
R 71424+6
摘要:
目的分析妊娠期高血压对慢性乙型肝炎孕妇妊娠结局及新生儿的影响。方法回顾性分析2015年1月至2017年8月三水区人民医院产科收治的乙肝抗原阳性孕妇128例的临床资料，其中合并妊娠期高血压的40例患者作为研究组，未出现妊娠期高血压的88例患者作为对照组。比较两组患者胎膜早破、胎盘早剥、羊水过多、产后大出血、产褥感染等发生率，及新生儿畸形/死胎、巨大儿、早产儿、胎儿宫内窘迫等发生率，并分析慢性乙型肝炎患者发生妊娠期高血压的相关危险因素。结果研究组患者胎膜早破、羊水过多和产褥感染的发生率高于对照组，差异有统计学意义（P<005）；两组胎盘早剥和产后大出血发生率比较，差异无统计学意义（P>005）。研究组患者巨大儿、早产儿、胎儿窘迫、黄疸发生率高于对照组，差异有统计学意义（P<005）；两组新生儿畸形/死胎发生率比较，差异无统计学意义（P>005）。Logistic回归分析显示高龄（OR=114，95 % CI:101129）、不良情绪（OR=122，95 % CI:103162）、未定期产前检查（OR=127，95 % CI:108149）、有妊娠期高血压疾病家族史（OR=305，95 % CI:162485）、产前未正规治疗乙肝（OR=133，95 % CI:106167）是发生妊娠期高血压的危险因素。结论妊娠期高血压对慢性乙型肝炎孕妇妊娠结局及新生儿有一定的影响。
Abstract:
ObjectiveTo analyze the effect of pregnancyinduced hypertension on the pregnancy outcome of pregnant women with chronic hepatitis B and neonates.MethodsTo retrospectively analyze the clinical data of 128 pregnant women with hepatitis B antigen positive who were admitted to the Obstetrics Department of Sanshui District People's Hospital from January 2015 to August 2017.Among them, 40 patients with pregnancyinduced hypertension were included in the study group, and 88 patients without pregnancyinduced hypertension patients served as the control group. Compared the prevalence of premature rupture of membranes, placental abruption, polyhydramnios, postpartum hemorrhage, puerperal infection and other pregnancy outcomes, and the incidence of neonatal malformation/stillbirth, giant infants, premature infants, fetal distress and analyzed the risk factors associated with pregnancyinduced hypertension in patients with chronic hepatitis B. ResultsThe incidence of premature rupture of membranes, polyhydramnios and puerperal infection in the study group was higher than that in the control group, the difference was statistically significant (P<005); the incidence of placental abruption and postpartum hemorrhage between the two groups was not statistically different (P>005). The incidence of giant infants, premature infants, fetal distress, and jaundice in the study group was higher than that in the control group, and the difference was statistically significant (P<005); there was no statistically significant difference in the incidence of neonatal malformation / stillbirth between the two groups (P>005) . Logistic regression analysis showed that advanced age (OR=114,95 % CI:1.011.29), bad mood (OR=122,95 % CI:103162), unscheduled prenatal checkup (OR=127,95 % CI:108149), a family history of hypertension in pregnancy (OR=305, 95 % CI:162485) and prenatal treatment of hepatitis B (OR=133, 95 % CI:106167) were high incidence of pregnancy risk factors for hypertension during pregnancy.ConclusionHypertension during pregnancy has a certain effect on the pregnancy outcome of pregnant women with chronic hepatitis B and neonates.

参考文献/References:

［1］Pan C Q,Lee H M.Antiviral therapy for chronic hepatitis B in pregnancy ［J］.Seminars in Liver Disease,2013,33(2):138146. ［2］Bramham K, Parnell B, Nelson Plercy C, et al. Chronic hypertension and pregnancy outcomes: systematic review and metaanalysis ［J］. BMJ (Clinical Research ed.), 2014, 348: g 2301. ［3］徐飚，刘兰华，陈洁，等．孕妇乙型肝炎病毒携带对其新生儿围产期结局及远期生长的影响 ［J］．中国妇幼保健，2014，29（24）：39533955． ［4］Xin Huang, Tan Hongzhuan, Xun Li, et al. Maternal chronic HBV infection would not increase the risk of pregnancyinduced hypertensionresults from pregnancy cohort in liuyang rural China ［J］. PLOS One,2014,9(12):e 114248. ［5］Mohan P, Kuppusamy S S, Mukherjee A, et al. Epidemiology, clinical features, serological markers, and outcome of chronic hepatitis B in pregnancy ［J］. Journal of Clinical and Experimental Hepatology, 2017,7:S 28. ［6］李飞凤，黄启涛，马思原，等．慢性乙型肝炎孕妇HBeAg阳性与不良妊娠结局关系研究 ［J］．中国实用妇科与产科杂志，2016，32（7）：680684． ［7］张媛，郭佩玲，王青青，等．妊娠期慢性乙型肝炎病毒携带者病毒载量与妊娠结局的相关性 ［J］．中山大学学报(医学科学版),2014，35（6）：866869． ［8］Giuseppina L, Pinnetti C, Floridia M, et al. Pregnancy outcomes in HIVinfected women of advanced maternal age ［J］. HIV Clinical Trials, 2013, 14(3): 110119. ［9］卢亚凤，李亚飞，袁宏霞．妊娠期高血压疾病的临床研究进展 ［J］．医学信息，2012，25（1）：457458． ［10］刘发莲，许梅，常兵．不同年龄妊娠合并慢性高血压患者妊娠结局及新生儿预后 ［J］．现代诊断与治疗，2015，26（3）：649650． ［11］王晔．妊娠期高血压孕妇相关危险因素调查与预防管理措施 ［J］．中医药管理杂志，2016，24（20）：1112． ［12］张珂．妊娠期高血压危险因素及其对妊娠孕产妇结局的影响分析 ［J］．中国民康医学，2015，27（13）：4950．

相似文献/References:

[1]王金光,乔宠,刘彩霞,等.双胎妊娠并发妊娠期高血压的危险因素[J].中国计划生育和妇产科,2016,(03):0.
[2]纪国欣,赵慧栋,吴纪芬,等.妊娠期高尿酸血症研究新进展[J].中国计划生育和妇产科,2016,(03):0.
[3]芦笛,白伶俐.妊娠期糖尿病合并多囊卵巢综合征患者的不良临床结局分析[J].中国计划生育和妇产科,2016,(10):0.
　LU Di,BAI Lin-lird.[J].Chinese Journal of Family Planning & Gynecotokology,2016,(7):0.
[4]张政梅,梁娜*.慢性乙肝病毒感染孕妇替比夫定治疗前后血清谷丙转氨酶、总胆红素、乙肝病毒DNA及标志物与细胞因子水平变化[J].中国计划生育和妇产科,2018,(10):50.
　ZHANG Zheng-mei,LIANG Na*.Serum levels of alanine aminotransferase, total bilirubin, hepatitis B virus DNA and its markers, cytokines in pregnant women with chronic hepatitis B virus infection before and after treatment of telbivudine[J].Chinese Journal of Family Planning & Gynecotokology,2018,(7):50.
[5]李莹,刘沛红,危玲,等.多囊卵巢综合征患者孕前体质量指数对妊娠期 高血压疾病的影响[J].中国计划生育和妇产科,2020,(2):41.
　LI Ying,LIU Pei-hong,WEI Ling,et al.Effect of pre-pregnancy body mass index in patients with polycystic ovarian syndrome on hypertensive disorder complicating pregnancy[J].Chinese Journal of Family Planning & Gynecotokology,2020,(7):41.

备注/Memo

备注/Memo:
佛山市自筹经费类科技计划项目（项目编号：2017372）
更新日期/Last Update: 2020-07-25