[1]闵爱萍*,罗晓,冯欣,等.乐山市育龄女性叶酸代谢关键酶基因多态性与 不良孕产相关性研究[J].中国计划生育和妇产科,2020,(2):69-71.
 MIN Ai-ping*,LUO Xiao,FENG Xin,et al.MTHFR and MTRR gene polymorphisms correlation with adverse pregnancy history in women of childbearing age in Leshan City[J].Chinese Journal of Family Planning & Gynecotokology,2020,(2):69-71.
点击复制

乐山市育龄女性叶酸代谢关键酶基因多态性与 不良孕产相关性研究
分享到:

《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2020年2期
页码:
69-71
栏目:
论著与临床
出版日期:
2020-02-25

文章信息/Info

Title:
MTHFR and MTRR gene polymorphisms correlation with adverse pregnancy history in women of childbearing age in Leshan City
作者:
闵爱萍1*罗晓1冯欣1张惠林1许洪梅1梁琼华1鲁衍强2胡季芳2
1614000四川乐山,乐山市人民医院妇产科;2201314上海,上海张江普汇转化医学研究院研发部
Author(s):
MIN Ai-ping1* LUO Xiao1 FENG Xin1 ZHANG Hui-lin1 XU Hong-mei1LIANG Qiong-hua1 LU Yan-qiang2 HU Ji-fang2
1.Department of Obstetrics and Gynecology,People's Hospital of Leshan,Leshan Sichuan 614000,P.R.China;2.R & D department,Shanghai Zhangjiang Puhui Translational Medicine Research Institute, Shanghai 201314,P.R.China
关键词:
510-亚甲基四氢叶酸还原酶甲硫氨酸合成酶还原酶不良孕产基因
Keywords:
MTHFR MTRR adverse pregnancy gene
分类号:
R 715
摘要:
目的调查研究乐山市育龄妇女叶酸代谢关键酶基因5,10-亚甲基四氢叶酸还原酶(5,10-methylenetetrahydrofolate reductase,MTHFR) C 677 T、A 1298 C、甲硫氨酸合成酶还原酶(Methionine synthase reductase,MTRR)A 66 G基因位点遗传特异性与不良孕产的相关性。方法选取2016~2019年到乐山市人民医院进行围孕期保健的育龄女性, 曾有不良孕产的女性100例为病例组,正常女性208例为对照组,采集口腔黏膜细胞,提取人体
Abstract:
ObjectiveTo investigate the 5,10-methylenetetrahydrofolate reductase (MTHFR) C 677 T, A 1298 C, Methionine synthase reductase (MTRR) A66G gene locus genetic correlation and poor motherhood in women of childbearing age in Leshan City.MethodsFrom 2016 to 20

参考文献/References:

[1]Ukowski R, Malone F D, Porter F T, et al. Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study [J]. PLOS Medicine, 2009, 6 (5): 635-636. [2]邓婕,有风芝,程国梅,等.ACE,AT_1R,eNOS基因多态性与重度子痫前期的相关性 [J].中国妇幼保健,2010,25(35):5277-5279. [3]贺宪民,张群,杨琦,等.亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶基因多态性研究 [J].中国计划生育学杂志,2010,18(1):13-18. [4]Kimura M, Higuchi M M. Methylenetetrahydrofolate reductase C677T polymorphism,folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes [J]. Journal of Nutrition, 2004, 134 (1): 48-56. [5]Harisha P N, Devi B I, Christopher R, et al. Impact of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects [J]. Journal of Neurosurgery - Pediatrics, 2010, 6 (4): 364-367. [6]Erdogan M O, Yildiz S H, Solak M, et al. C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid,vitamin B12,and homocysteine serum levels in Turkish children with neural tube defects [J]. Genetics&Molecular Research Gmr, 2010, 9 (2): 1197-1203. [7]Yenicesu G I, Cetin M, Ozdemir O, et al. ORIGINAL ARTICLE:A prospective case–control study analyzes 12 thrombophilic gene mutations in Turkish couples with recurrent pregnancy loss [J]. American Journal of Reproductive Immunology, 2010, 63 (2): 126-136. [8]Coppede F, Migheli F, Bargagna S A, et al. Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring [J]. Neuroscience Letters, 2009, 449 (1): 15-19. [9]Harisha P N, Devi B I, Christopher R, et al. Impact of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects [J]. Journal of Neurosurgery - Pediatrics, 2010, 6 (4): 364-367. [10]Homocysteine T E, Mthfr, Polymorphisms G. Andcardio-cerebrovascular risk [J]. Journal of Applied Genetics, 2008, 49 (3): 267-282. [11]Mtiraoui N, Zammiti W, Ghazouani L, et al. Methylenetetrahydrofolate reductase C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent pregnancy losses [J]. Reproduction, 2006, 131 (2): 395-401. [12]Krause M, Sonntag B, Klamroth R, et al. Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage - Results of a multicentre case-control study [J]. Thrombosis and Haemostasis, 2005, 93 (5): 867-871. [13]从玉英,鲁衍强,芮欣忆,等.淄博市汉族女性亚甲基四氢叶酸还原酶和甲硫氨酸合成酶还原酶基因多态性分布研究 [J].现代妇产科进展,2012,21(10):779-781.

备注/Memo

备注/Memo:
中国疾病预防控制中心妇幼保健中心妇幼保健分子遗传医学研究专项计划(项目编号:FY-ZX-ZD-0283);乐山市2018年重点科技计划项目(项目编号:18SZD150)
更新日期/Last Update: 2020-02-25