[1]王雪娇,田东梅,尹欣,等.冻融胚胎移植后异位妊娠类型分析及危险因素探讨[J].中国计划生育和妇产科,2020,(7):29-33.
　WANG Xuejiao,TIAN Dongmei,YIN Xin,et al.Analysis of the types of ectopic pregnancy and the risk factors after freezethaw embryo transfer[J].Chinese Journal of Family Planning & Gynecotokology,2020,(7):29-33.
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冻融胚胎移植后异位妊娠类型分析及危险因素探讨
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2020年7期
页码:
29-33
栏目:
辅助生殖研究专栏
出版日期:
2020-07-25

文章信息/Info

Title:
Analysis of the types of ectopic pregnancy and the risk factors after freezethaw embryo transfer
作者:
王雪娇; 田东梅; 尹欣; 李亨利; 朱明辉*
成都中医药大学医学与生命科学学院
Author(s):
WANG Xuejiao; TIAN Dongmei; YIN Xin;  LI Hengli; ZHU Minghui*
School of Medicine and Life Science, Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 611130,P.R.China
关键词:
冻融胚胎移植; 异位妊娠; 危险因素
Keywords:
freezethaw embryo transfer; ectopic pregnancy; risk factors
分类号:
R 71422
摘要:
目的探讨辅助生殖技术（assisted reproductive technology,ART)中,行冻融胚胎移植（freezethaw embryo transfer,FET）后发生异位妊娠的类型及危险因素。方法收集2013年1月至2017年12月在成都中医药大学附属生殖妇幼医院生殖中心行FET后获得临床妊娠的1 101例患者的临床资料，分为异位妊娠组和非异位妊娠组，统计异位妊娠类型及妊娠结局，并对异位妊娠危险因素进行单因素分析。结果1 101例临床妊娠患者中，异位妊娠共35例（318 %），其中同时非同位妊娠（heterotopic pregnancy, HP）6例(054 %)，宫角妊娠2例(018 %) ；其中卵裂期胚胎发生率526 %（33/627），囊胚期发生率042 %（2/474），1 066例非异位妊娠患者，自然流产143例（1299 %），新生儿死亡6例（054 %），死胎5例（045 %）。单因素分析显示，异位妊娠组既往异位妊娠史、流产史、盆腔因素所致不孕占比均高于非异位妊娠组（P<005），卵裂期胚胎移植异位妊娠发生率高于囊胚期（P<005），单胚胎移植异位妊娠率显著降低（P<005）。结论FET后HP发生率增加。盆腔及输卵管因素仍为异位妊娠发生的重要原因。囊胚期胚胎移植及单胚胎移植异位妊娠发生率显著降低。
Abstract:
ObjectiveTo investigate the types and risk factors of ectopic pregnancy(EP) after freezethaw embryo transfer(FET) in assisted reproductive technology(ART).MethodsClinical data of 1 101 patients with clinical pregnancy were collected between January 2013 and December 2017 after FET performed in the Reproductive Maternity and Child Hospital Affiliated to Chengdu University of Traditional Chinese Medicine.Patients were divided into EP and nonEP groups. Types of EP and pregnancy outcome were tracked, while risk factors were analyzed using single factor analysis. ResultsOut of the 1 101 patients, 35 experienced EP(318 %), out of which 6 cases (054 %) were heterotopic pregnancy (HP), 2 cases (018 %) were horn pregnancy.Within which cleavage stage embryos experienced EP rate of 526 % (33/627), while blaetocyst stage embryos experienced EP rate of 042 % (2/474).Of the 1 066 nonEP patients, 143 were spontaneous abortions (1299 %),6 were neonatal deaths (054 %), and 5 were stillbirths (045 %).Single factor analysis showed that in the frozen embryo transplantation, higher EP rates were observed in cases with previous EP history, previous abortion history and infertility caused by pelvic factors(P<005); Rate of EP is higher in cleavage stage than in blaetocyst stage(P<005);Single embryo transfer yields lower EP rates (P<005).ConclusionThe incidence of HP is likely to increase after FET. Pelvic cavity and oviduct in frozen embryo group are still the main causes of EP. Incidence of EP during blastocyst embryo transfer and single embryo transfer is significantly lower.

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备注/Memo

备注/Memo:
四川省科技厅科技成果转化项目（项目编号:2017YSZH0032）；成都中医药大学校级基金项目（项目编号:ZRQN1704）
更新日期/Last Update: 2020-07-25