[1]王安然*,周莉,莫似恩,等.不同内膜准备方案对剖宫产术后患者冻融囊胚 移植周期临床结局的影响[J].中国计划生育和妇产科,2020,(7):17-21.
　WANG Anran*,ZHOU Li,MO Sien,et al.Effects of different endometrial preparation schemes on the clinical outcome of freezethaw blastocyst transfer cycles in patients after cesarean section[J].Chinese Journal of Family Planning & Gynecotokology,2020,(7):17-21.
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不同内膜准备方案对剖宫产术后患者冻融囊胚 移植周期临床结局的影响
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《中国计划生育和妇产科》[ISSN:1674-4020/CN:51-1708/R]

卷:
期数:
2020年7期
页码:
17-21
栏目:
辅助生殖研究专栏
出版日期:
2020-07-25

文章信息/Info

Title:
Effects of different endometrial preparation schemes on the clinical outcome of freezethaw blastocyst transfer cycles in patients after cesarean section
作者:
王安然*; 周莉; 莫似恩; 黄晖; 邓立
广西壮族自治区生殖医院生殖医学科
Author(s):
WANG Anran*; ZHOU Li; MO Sien; HUANG Hui; DENG Li
Department of Reproductive Medicine,The Guangxi Zhuang Autonomous Region Reproductive Hospital,Nanning Guangxi 530021,P.R.China
关键词:
剖宫产术后; 冻融囊胚移植; 内膜准备; 妊娠结局
Keywords:
postcesarean section; freezethaw blastocyst transplantation;  endometrial preparation; pregnancy outcome
分类号:
R 3291
摘要:
目的探讨不同子宫内膜准备方案对剖宫产术后患者冻融囊胚移植周期临床结局的影响。方法回顾性分析2017年1月至2018年12月于广西壮族自治区生殖医院行冻融胚胎移植（frozenthawed embryo transfer，FET）的1 000例剖宫产术后患者的病历资料，根据内膜准备方案分为A组:自然周期(nature cycle,NC)426例，B组:人工周期(hormone replace treatment,HRT）429例，C组:促排卵方案74例，D组:降调节后人工周期（gonadotrophin releasing hormone agonisthormone replace treatment，GnRHaHRT）71例，比较4组患者的基本情况及妊娠结局。结果4组患者年龄、剖宫产年限、移植胚胎个数比较，差异无统计学意义（P＞005），4组胚胎冷冻年限、剖宫产年限、移植优质囊胚率、临床妊娠率、新生儿平均出生体重比较，差异均有统计学意义（P＜005）；4组种植率、流产率、异位妊娠率、多胎率、早产率、活产率、低出生体重儿比较，差异均无统计学意义（P＞005）；Logistic多因素回归分析患者年龄、胚胎移植个数、移植优胚数是临床妊娠率的独立影响因素（P＜005），胚胎冷冻年限、剖宫产年限、子宫内膜厚度、内膜准备方案并不是临床妊娠率的影响因素（P＞005）。结论对于剖宫产术后行FET患者各种内膜准备方案均适用，但自然周期和GnRHaHRT方案可能存在一定的优势，但其结论尚需大样本、前瞻性多中心随机对照研究进一步证实。
Abstract:
ObjectiveTo explore the effect of different endometrial preparations on the clinical outcome of freezethaw blastocyst transplantation in patients after cesarean section.MethodsA retrospective analysis of the medical records of 1 000 cesarean section patients undergoing frozenthawed embryo transfer (FET) at The Guangxi Zhuang Autonomous Region Reproductive Hospital from January 2017 to December 2018, according to the preparation plan of intima was divided into 426 cases in group A ［nature cycle (NC)］, 429 cases in group B ［artificial cycle (hormonereplacetreatment, HRT)］, 74 cases in group C (ovulation promotion plan), and 71 cases in group D after deregulation Artificial cycle ［(gonadotrophin releasing hormone agonisthormonereplacetreatment, GnRHaHRT)］,compare the basic conditions and pregnancy outcomes of the 4 groups of patients.ResultsThere were no statistically significant differences in the age, cesarean section and the number of embryos transferred between the 4 groups (P>005). There were significant differences in freezing years of the embryos, the years of cesarean section, the rate of highquality blastocyst transplantation,the clinical pregnancy rate and the average birth weight of newborn among the four groups(P<005); the comparison of the implantation rate, miscarriage rate, multiple birth rate, premature birth rate, live birth rate, and birth rate of lowbirthweight infants among the four groups had no statistical significance (P>005); Logistic multivariate regression analysis of patient′s age, number of embryos transferred, and number of excellent embryos transferred are independent influencing factors of clinical pregnancy rate (P<005), years of embryo freezing, years of cesarean section, endometrial thickness, endometrial preparation were not the influencing factors of clinical pregnancy rate (P>005).ConclusionVarious endometrial preparations are applicable to patients undergoing FET after cesarean section, but natural cycles and GnRHaHRT may have certain advantages, but their conclusions need to be further confirmed by a large sample, prospective multicenter randomized controlled study.

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更新日期/Last Update: 2020-07-25